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Bunazosin hydrochloride

Bunazosin hydrochloride structure

CAS No:
52712-76-2
Formula:
C19H27N5O3.ClH
Chemical Name:
Bunazosin hydrochloride
Synonyms:
1-Butanone,1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1H-1,4-diazepin-1-yl]-,hydrochloride (1:1);1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride;E 643;DDQ;DDQ (pharmaceutical);Bunazosin hydrochloride;Detantol;1-(4-(4-Imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one hydrochloride;1-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one hydrochloride
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Bunazosin hydrochloride is a member of quinazolines.

Bunazosin hydrochloride Basic Attributes

Molecular Weight：

409.91

Exact Mass：

409.188080

UNII：

18V54TZ7U6

DSSTox ID：

DTXSID7048588

HScode：

2933990090

Characteristics

PSA：

93.8

XLogP3：

3.45410

Density：

1.221g/cm3

Melting Point：

280-282 °C

Boiling Point：

620.6ºC at 760mmHg

Flash Point：

329.1ºC

Toxicity：

Oral-rat LD50: 980 mg/kg; Oral-Mouse LD50:1201 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

MeSH Entry Terms：

4-amino-2-(4-butanoylhexahydro-1H-1,4-diazepin-1-yl)-6,7-dimethoxyquinazoline HCl

Bunazosin hydrochloride Use and Manufacturing

It is an αl-receptor blocker and hardly affects heart rate. Used for hypertension caused by primary, renal and pheochromocytoma.

Computed Properties

Molecular Weight:409.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:409.1880675
Monoisotopic Mass:409.1880675
Topological Polar Surface Area:93.8
Heavy Atom Count:28
Complexity:494
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Benzonitrile

Sodium benzoate

Drug Function and Efficacy

No specific pharmacological effects are clearly mentioned from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ditanto Bunazosin Hydrochloride Tablets

Ditanto Bunazosin Hydrochloride

Registered Holders

ESTECHPHARMA CO.,LTD.

Japan
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