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Home > Encyclopedia > (-)-Isoproterenol hydrochloride

(-)-Isoproterenol hydrochloride

pharmaceutical raw materials
(-)-Isoproterenol hydrochloride structure

(-)-Isoproterenol hydrochloride 

structure
  • CAS No:

    5984-95-2

  • Formula:

    C11H17NO3.ClH

  • Chemical Name:

    (-)-Isoproterenol hydrochloride

  • Synonyms:

    1,2-Benzenediol,4-[(1R)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]-,hydrochloride (1:1);Benzyl alcohol,3,4-dihydroxy-α-[(isopropylamino)methyl]-,hydrochloride,(-)-;1,2-Benzenediol,4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-,hydrochloride,(R)-;1,2-Benzenediol,4-[(1R)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]-,hydrochloride;(-)-Isoprenaline hydrochloride;(-)-Isopropyl arterenol hydrochloride;l-Isoproterenol hydrochloride;(-)-Isoproterenol hydrochloride;l-Isoprenaline hydrochloride;N-Isopropylnoradrenaline hydrochloride;l-Isoprenaline chloride;(R)-Isoproterenol hydrochloride;(R)-Isoprenaline hydrochloride

  • Categories:

    Active Pharmaceutical Ingredients  >  Respiratory Drugs

(-)-Isoproterenol hydrochloride Basic Attributes

247.72

247.09800

200-089-8

Characteristics

72.7

2.32210

Isoproterenol hydrochloride is an odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air. (NTP, 1992)

175 °C (dec.)(lit.)

441.5ºC at 760 mmHg

220.8ºC

Soluble (NTP, 1992)

−20°C

Safety Information

NONH for all modes of transport

3

36/37/38

26-36

DO1926000

Xi

P261-P305 + P351 + P338

H315-H319-H335

Drug Function and Efficacy

This product is a α receptor agonist, which has a strong stimulatory effect on both α1 and α2 receptors, and has almost no effect on α receptors. Main effects: ① Acting on the α1 receptor of the heart, it increases the heart contraction force, speeds up the heart rate, accelerates conduction, and increases cardiac output and myocardial oxygen consumption. ② Acting on the α2 receptor of vascular smooth muscle, it causes significant dilation of skeletal muscle blood vessels, and also dilation of kidney, mesenteric blood vessels and coronary arteries to varying degrees, and reduces the total peripheral resistance of blood vessels. Its cardiovascular effect leads to increased systolic blood pressure, decreased diastolic blood pressure, and increased pulse pressure difference. ③ Acting on the α2 receptor of bronchial smooth muscle, it relaxes the bronchial smooth muscle. ④ Promotes the decomposition of glycogen and fat and increases tissue oxygen consumption.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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