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Flutropium bromide

Flutropium bromide structure

CAS No:
63516-07-4
Formula:
C24H29FNO3.Br
Chemical Name:
Flutropium bromide
Synonyms:
8-Azoniabicyclo[3.2.1]octane,8-(2-fluoroethyl)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8-methyl-,bromide (1:1),(3-endo,8-syn)-;8-Azoniabicyclo[3.2.1]octane,8-(2-fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-,bromide,(endo,syn)-;8-Azoniabicyclo[3.2.1]octane,8-(2-fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-,bromide,(3-endo,8-syn)-;Ba 598Br;Flutropium bromide;Flubron
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Flutropium bromide is the organic bromide salt of flutropium. It is used in Japan for the treatment asthma and chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist, an antispasmodic drug and an anti-asthmatic drug. It contains a flutropium.

Flutropium bromide Basic Attributes

Molecular Weight：

478.39

Exact Mass：

477.13100

EC Number：

1533716-785-6

UNII：

K3V6HB0M57

DSSTox ID：

DTXSID3048655

Characteristics

PSA：

46.53000

XLogP3：

0.53800

Melting Point：

192-193 °C (decomp)

Toxicity：

LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner)

Drug Information

MeSH Entry Terms：

8-(2-fluoroethyl)-3 alpha-hydroxy-1 alpha H,5 alpha H-tropanium bromide benzilate

Flutropium bromide Use and Manufacturing

Atropine derivatives are parasympathetic blockers. The main role is anti-acetylcholine, also has anti-histamine effect. Used for bronchial occlusion and rhinitis.

Computed Properties

Molecular Weight:478.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:477.13148
Monoisotopic Mass:477.13148
Topological Polar Surface Area:46.5
Heavy Atom Count:30
Complexity:539
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Hydrochloric acid