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Dipivefrin hydrochloride

Dipivefrin hydrochloride structure

CAS No:
64019-93-8
Formula:
C19H29NO5.ClH
Chemical Name:
Dipivefrin hydrochloride
Synonyms:
Propanoic acid,2,2-dimethyl-,1,1′-[4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene] ester,hydrochloride (1:1);Propanoic acid,2,2-dimethyl-,4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester,hydrochloride,(±)-;Propanoic acid,2,2-dimethyl-,4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester,hydrochloride;Dipivefrin hydrochloride;Pivalephrine;Diopine;D Epifrin;Propine;Diphemin;Dipivefrine hydrochloride;42145-93-7
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

White or almost white, crystalline powder.

Dipivefrin hydrochloride is the hydrochloride salt of dipivefrin. It is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. It has a role as an adrenergic agonist, a sympathomimetic agent and an antiglaucoma drug. It contains a dipivefrin(1+).

Dipivefrin hydrochloride Basic Attributes

Molecular Weight：

387.8982

Exact Mass：

387.18100

EC Number：

264-609-5

DSSTox ID：

DTXSID2045494

HScode：

2922504500

Characteristics

PSA：

84.9

XLogP3：

4.03530

Melting Point：

158-159 °C

Boiling Point：

473.7ºC at 760 mmHg

Flash Point：

240.3ºC

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

Drug Information

MeSH：

Drugs that bind to and activate adrenergic receptors. (See all compounds classified as Adrenergic Agonists.)

MeSH Entry Terms：

adrenaline dipivalate

Dipivefrin hydrochloride Use and Manufacturing

Uses

Adrenergic (ophthalmic)

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:387.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:387.1812508
Monoisotopic Mass:387.1812508
Topological Polar Surface Area:84.9
Heavy Atom Count:26
Complexity:463
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Dipifoline is a prodrug of adrenaline. It has no biological activity. After entering the ocular tissue, it is hydrolyzed into adrenaline and exerts biological effects, causing mydriasis and lowering intraocular pressure. The intraocular pressure lowering effect works by reducing aqueous humor secretion and improving aqueous humor flow coefficient. After one drop of 0.1% dipifoline solution is injected into the eye, intraocular pressure begins to be lowered 30 minutes later, and the maximum effect is achieved in 1 to 2 hours, which lasts for about 10 to 12 hours. It has an additive effect when used in combination with pilocarpine or b-adrenergic receptor blockers.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dipifovir hydrochloride eye drops
Ingredients	The main ingredient of this product is dipivefrin hydrochloride, and the dipivefrin hydrochloride content should be 90.0-115.0% of the labeled amount. Chemical name: 2,2-dimethylpropionic acid 4-[1-hydroxy-2 (methylamino) ethyl]-1,2-phenylene hydrochloride. Molecular formula: C19H29NO5HCl Molecular weight: 387.90
Indication	There is an additive effect when used in combination with pilocarpine or b-adrenergic receptor blockers.
Specifications	8 ml: 8 mg
Manufacturer	Shenyang XINGQI Pharmaceutical Co., Ltd.

Dipifoline Hydrochloride
Manufacturer	Wuhan Wuyao Pharmaceutical Co., Ltd.

Dipifovir hydrochloride eye drops
Ingredients	The main ingredient of this product is dipivefrin hydrochloride, and the dipivefrin hydrochloride content should be 90.0-115.0% of the labeled amount. Chemical name: 2,2-dimethylpropionic acid 4-[1-hydroxy-2 (methylamino) ethyl]-1,2-phenylene hydrochloride. Molecular formula: C19H29NO5HCl Molecular weight: 387.90
Indication	There is an additive effect when used in combination with pilocarpine or b-adrenergic receptor blockers.
Specifications	5ml:5mg

See More Related Drugs

Registered Holders

China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active
Wuhan Wuyao Pharmaceutical Co., Ltd.

China
Active
PHARMECO LABORATORIES INC

United States
Inactive

See More Registered Holders