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Oxiconazole nitrate

Oxiconazole nitrate structure

CAS No:
64211-46-7
Formula:
C18H13Cl4N3O.HNO3
Chemical Name:
Oxiconazole nitrate
Synonyms:
Ethanone,1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-,O-[(2,4-dichlorophenyl)methyl]oxime,(1Z)-,mononitrate (1:1);Ethanone,1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-,O-[(2,4-dichlorophenyl)methyl]oxime,(Z)-,mononitrate;Ethanone,1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-,O-[(2,4-dichlorophenyl)methyl]oxime,(1Z)-,mononitrate;Oxiconazole nitrate;Oxistat;Ro 13-8996;Gyno-Myfungar;Oceral;Sgd 301-76;Myfungar;ST 813;Scorba LX;104360-36-3
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Oxiconazole nitrate is a broad spectrum antifungal which can inhibit the growth of T. tonsurans and T. rubrum with MIC90s of 0.25 and 0.5 μg/mL, respectively.

Oxiconazole nitrate Basic Attributes

Molecular Weight：

429.13

Exact Mass：

491.973966

EC Number：

264-730-3

DSSTox ID：

DTXSID2045943

HScode：

29335995

Characteristics

PSA：

105.46000

XLogP3：

6.15550

Melting Point：

137-138 °C

Boiling Point：

576.8ºC

Flash Point：

302.6ºC

Storage Conditions：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

37/39-26-36

RTECS Number：

CQ7700000

Marks：

GHS Classification：

|Warning|H302 (92.31%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, and P501|Aggregated GHS information provided by 27 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

(Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-O-(2,4-dichlorobenzyl) ethanone oxime nitrate

Oxiconazole nitrate Use and Manufacturing

Uses

radiopaque agent

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:492.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:491.973966
Monoisotopic Mass:489.976916
Topological Polar Surface Area:106
Heavy Atom Count:30
Complexity:506
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Hydroxylamine hydrochloride

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Oxiconazole nitrate cream
Ingredients	The active ingredient of this product is oxiconazole nitrate.
Indication	If other drugs are used at the same time and drug interactions occur, please consult your doctor or pharmacist for details.
Specifications	15g:0.15g (calculated as C18H13Cl4N3O)
Manufacturer	Hunan Zonwe Pharm Co., Ltd.

Oxyconazole Nitrate
Specifications	－－－－
Manufacturer	Hunan Zonwe Pharm Co., Ltd.

Registered Holders

METROCHEM API PRIVATE LTD

United States
Active
Hunan Zonwe Pharm Co., Ltd.

China
Active
Siegfried Ltd

United States
Active

See More Registered Holders

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Oxiconazole nitrate

CAS No.: 64211-46-7

Grade: industrial Grade

Content: 98%

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