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Apraclonidine hydrochloride

Apraclonidine hydrochloride structure

CAS No:
73218-79-8
Formula:
C9H10Cl2N4.ClH
Chemical Name:
Apraclonidine hydrochloride
Synonyms:
1,4-Benzenediamine,2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-,hydrochloride (1:1);1,4-Benzenediamine,2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-,monohydrochloride;1,4-Benzenediamine,2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)-,monohydrochloride;p-Aminoclonidine monohydrochloride;ALO 2145;Apraclonidine hydrochloride;AL 02145;Iopidine;Aplonidine hydrochloride;2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride;87913-86-8
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

Crystalline Solid

Apraclonidine hydrochloride is the hydrochloride salt of apraclonidine. It has a role as an alpha-adrenergic agonist and an antiglaucoma drug. It contains an apraclonidine.|Apraclonidine Hydrochloride is the hydrochloride salt form of apraclonidine, a clonidine derivative with selective alpha-2-adrenergic agonistic property. When administered directly to eyes, apraclonidine hydrochloride enhances aqueous humor outflow and decreases aqueous production by vasoconstriction. It is used mostly in ophthalmic preparations for decreasing intraocular pressure.

Apraclonidine hydrochloride Basic Attributes

Molecular Weight：

281.57

Exact Mass：

280.00500

UNII：

D2VW67N38H

DSSTox ID：

DTXSID6045749

NCI Thesaurus Code：

C47401

HScode：

2933290090

Characteristics

PSA：

62.4

XLogP3：

3.16730

Appearance：

white solid

Density：

1.63 g/cm3

Melting Point：

>2300C

Boiling Point：

395.5ºC at 760 mmHg

Flash Point：

193ºC

Water Solubility：

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL Solutions may be stored for several days at 4?#x00b0;C

Storage Conditions：

2-8°C

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 1

wgk germany：

hazard class code：

23/24/25

safety instructions：

22-36/37/39-45

Marks：

Stability/Shelf Life：

Moisture Sensitive

Precautionary statement(s)：

Missing Phrase - N15.00950417-P308 + P311

Hazard Statements：

H300-H370

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

MeSH Entry Terms：

2-(4-amino-2,6-dichloro)phenyliminoimidazolidine

Apraclonidine hydrochloride Use and Manufacturing

Methods of Manufacturing

2- (2 ', 6'-Dichloro-4'-nitroanilino)-2-imidazoline27.4 g (0.1 mol), Hydrazine hydrate 11.8g (0.2mol), Added methanol 200mL, 5percent palladium carbon 0.3g, Plus heating reaction mixture was stirred for 2h, Cool, hot filtered.The filtrate was added hydrochloric acid 10mL, heated to reflux for 2 hours, Chilled to give a white solid Apraclonidine hydrochloride 20.2, yield 72.1percent

Uses

a-Adrenergic agonist; structural analog of clonidine. Used for treatment of post-surgical elevated intraocular pressure

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:281.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:280.004929
Monoisotopic Mass:280.004929
Topological Polar Surface Area:62.4
Heavy Atom Count:16
Complexity:247
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Apraclonidine Hydrochloride Eye Drops
Ingredients	The main ingredient of this product is Apraclonidine Hydrochloride.
Specifications	0.25ml:2.5mg

Apraclonidine Hydrochloride
Manufacturer	Shandong Chenlong Pharmaceutical Co., Ltd.

Registered Holders

Pcas

United States
Active
Shandong Chenlong Pharmaceutical Co., Ltd.

China
Active
FORMOSA LABORATORIES INC

United States
Active

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Apraclonidine hydrochloride made in china

CAS No.: 73218-79-8

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Apraclonidine hydrochloride

CAS No.: 73218-79-8

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Guide of Apraclonidine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Apraclonidine hydrochloride

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