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Iomeprol

Iomeprol structure

CAS No:
78649-41-9
Formula:
C17H22I3N3O8
Chemical Name:
Iomeprol
Synonyms:
1,3-Benzenedicarboxamide,N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)methylamino]-2,4,6-triiodo-;1,3-Benzenedicarboxamide,N,N′-bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-;N1,N3-Bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide;Iomeprol;Iomeron 350;Imeron;Iomeron;Imeron 300;1352150-90-3
Categories:
Active Pharmaceutical Ingredients > Diagnostic Agents

Description

White Solid

Iomeprol is a benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a glycoloyl(methyl)amino group at the 5-position. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. It is a benzenedicarboxamide and an organoiodine compound.|Iomeprol has been investigated for the diagnostic of Coronary Artery Disease.

Iomeprol Basic Attributes

Molecular Weight：

777.09

Exact Mass：

777.09

EC Number：

1533716-785-6

UNII：

17E17JBP8L

DSSTox ID：

DTXSID1049061

ATC Code：

V08AB10|V - Various

Characteristics

PSA：

180

XLogP3：

-3.08

Appearance：

White Solid

Density：

d420 1.166; d437 1.161; d420 1.334; d437 1.329; d420 1.446; d437 1.441

Melting Point：

263-265°C

Boiling Point：

813.2±65.0 °C at 760 mmHg

Flash Point：

445.6±34.3 °C

Refractive Index：

nD20 1.3828; nD20 1.4327; nD20 1.4660

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 (400 mgI/ml soln) i.v. in mice, rats (gI/kg): 19.9, 14.5; LD50 (370 mgI/ml soln) i.v. in dogs (gI/kg): >12.5 (Morisetti)

Collision Cross Section：

211.2 Å² [M-H]-

Drug Information

MeSH：

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

MeSH Entry Terms：

Imeron

Iomeprol Use and Manufacturing

Diagnostic aid (radiopaque medium) Intravenous urography (adults, including patients with kidney damage or diabetes), CT (trunk), conventional angiography, arterial DSA, cardiovascular angiography (adults and children), conventional selective coronary angiography, interventional coronary angiography, fistula Radiography, milk duct radiography, dacryocyst radiography, salivary duct radiography.

Computed Properties

Molecular Weight:777.1
XLogP3:-2.3
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:776.8541
Monoisotopic Mass:776.8541
Topological Polar Surface Area:180
Heavy Atom Count:31
Complexity:591
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific description provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Iomeprol Injection
Specifications	50ml:17.5g(I)

Iomeprol Injection
Specifications	50ml:17.5g(I)

Iomeprol Injection
Specifications	100ml:30g(I)

See More Related Drugs

Registered Holders

Bracco Imaging Medical Technologies (Shanghai) Co., Ltd.

China
Active
Zhejiang Hichi Pharmaceutical Corporation Limited

China
Active
Jiangsu Yutian Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Iomeprol

BrightGene Health Technology Co., Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of APIs,Veterinary,Cosmetic Ingredients,Peptides,intermediates,food ingredients

N1,N3-bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodoisophthalamide 99% GMP 99% White to Light Yellow

CAS No.: 78649-41-9

Grade: Pharmaceutical Grade

Content: 99%

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