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Fosinopril sodium

Fosinopril sodium structure

CAS No:
88889-14-9
Formula:
C30H46NO7P.Na
Chemical Name:
Fosinopril sodium
Synonyms:
L-Proline,4-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-,sodium salt (1:1),(4S)-;L-Proline,4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-,sodium salt,[1[S*(R*)],2α,4β]-;L-Proline,4-cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-,sodium salt,(4S)-;SQ 28555;Fosinopril sodium;Monopril;Staril;Acecor;Secorvas;Eosinopril;Fosenopril sodium
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI

Fosinopril sodium is the sodium salt of fosinopril. It is used for the treatment of hypertension and heart failure. A pro-drug, its phosphinate ester group is hydrolysed in vivo to give the corresponding phosphininc acid, fosinoprilat, which is the active metabolite. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It contains a fosinopril(1-).|A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.

Fosinopril sodium Basic Attributes

Molecular Weight：

586.65

Exact Mass：

563.301208

EC Number：

1312995-182-4

DSSTox ID：

DTXSID7046621

HScode：

2933990090

Characteristics

PSA：

113

XLogP3：

4.72450

Appearance：

white to off-white

Density：

1.2±0.1 g/cm3

Melting Point：

196-198°C

Boiling Point：

705.7°C at 760 mmHg

Flash Point：

380.6±35.7 °C

Refractive Index：

1.532

Water Solubility：

H2O: >20mg/mL

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

GHS Classification：

|Warning|H315 (88.52%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 61 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Dynacil

Fosinopril sodium Use and Manufacturing

Uses

Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:585.6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:15
Exact Mass:585.28313405
Monoisotopic Mass:585.28313405
Topological Polar Surface Area:113
Heavy Atom Count:40
Complexity:857
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Specifications	API

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Ingredients	Fosinopril sodium.
Specifications	10mg

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Registered Holders

HETERO DRUGS LTD

United Kingdom
Active
Zhe JIANG HUA HAI Pharmaceutical Co., Ltd.

China
Active
SINO-AMERICAN Shanghai Squibb Pharmaceuticals Ltd.

China
Active

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