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Ropivacaine hydrochloride

Ropivacaine hydrochloride structure

CAS No:
98717-15-8
Formula:
C17H26N2O.ClH
Chemical Name:
Ropivacaine hydrochloride
Synonyms:
2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-propyl-,hydrochloride (1:1),(2S)-;2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-propyl-,monohydrochloride,(S)-;2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-propyl-,monohydrochloride,(2S)-;AL 381;Ropivacaine hydrochloride;Naropin;85255-64-7
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

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Description

Ropivacaine hydrochloride is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM.

An anilide used as a long-acting local anesthetic. It has a differential blocking effect on sensory and motor neurons.

Ropivacaine hydrochloride Basic Attributes

Molecular Weight：

310.86

Exact Mass：

310.181183

EC Number：

1312995-182-4

UNII：

35504LBE2T

DSSTox ID：

DTXSID2048379

HScode：

2933399090

Characteristics

PSA：

32.34000

XLogP3：

4.31930

Appearance：

Density：

1.044 g/cm3

Melting Point：

260-262 °C

Boiling Point：

410.2ºC at 760 mmHg

Flash Point：

201.9ºC

Specific rotation：

D25 -6.6° (c = 2 in water)

Safety Information

GHS Classification：

|Danger|H302 (12.24%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P330, and P501|Aggregated GHS information provided by 49 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

MeSH Entry Terms：

1 Propyl 2',6' pipecoloxylidide

Ropivacaine hydrochloride Use and Manufacturing

Uses

anesthetic Ropivacaine is such a new type of long-acting amide local anesthetic. Its action lasts for a long time, and it has anesthetic and analgesic effects.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:310.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:310.1811912
Monoisotopic Mass:310.1811912
Topological Polar Surface Area:32.3
Heavy Atom Count:21
Complexity:308
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ropivacaine hydrochloride
Manufacturer	Shandong Keyuan Pharmaceutical Co., Ltd.

Ropivacaine Hydrochloride Injection
Ingredients	The main ingredient of this product is ropivacaine hydrochloride, and its chemical name is: S (-) 1-propyl N (2, 6-xylyl) 2-piperidinecarboxamide hydrochloride.
Indication	Because toxic effects are additive, caution should be exercised when this drug is used concomitantly in patients receiving other local anesthetics or drugs structurally related to amide local anesthetics.
Specifications	10 ml: 75 mg (based on C17H26N2O.HCl)
Manufacturer	Qilu Pharmaceutical Co., Ltd.

Ropivacaine Hydrochloride Injection
Ingredients	Ropivacaine hydrochloride
Indication	Because toxic effects are additive, patients receiving other local anesthetics or drugs structurally related to amide local anesthetics should be cautious when using ropivacaine hydrochloride injection concomitantly.
Specifications	75mg/10ml/vial

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Registered Holders

EXCELLA GMBH AND CO KG

United States
Active
FINE CHEMICALS CORP PTY LTD

United States
Active
Shanghai Cenway Int’l Trading Co., Ltd.

China
Active

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Guide of Ropivacaine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Ropivacaine hydrochloride

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