 Home > Encyclopedia > Tranexamic acid

Tranexamic acid

Tranexamic acid structure

CAS No:
1197-18-8
Formula:
C8H15NO2
Chemical Name:
Tranexamic acid
Synonyms:
Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;DV 79;AMCHA;Amikapron;trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Tranexamic acid;Transamin;Anvitoff;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid;Bay 3517;Cyklokapron;TAMCHA;trans-Amcha;Ugurol;Cyclocapron;Transamin S;Transamin G;trans-Tranexamic acid;AMCA;t-AMCHA;Xamig;Zataranax;Exacyl;CL 65336;Cyclokapron;4-trans-Aminomethylcyclohexanecarboxylic acid;Xed;Tranol;Haematrix;Transcam;HAKU;Amchafibrin;Lysteda;1628783-16-3
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. Target: OthersTranexamic acid is a synthetic derivative of the amino acid lysine. Tranexamic acid is frequently used in surgeries with high risk of blood loss such as cardiac, liver, vascular and large orthopedic procedures. Its oral form is now being evaluated for use in outpatient conditions involving heavy bleeding.Toxicity/Adver

Tranexamic acid Basic Attributes

Molecular Weight：

157.21

Exact Mass：

157.21

BRN：

2207452

EC Number：

214-818-2

HScode：

2922499990

Characteristics

PSA：

63.32000

XLogP3：

0.31

Appearance：

White Crystalline Powder

Density：

1.1±0.1 g/cm3

Melting Point：

>300 °C

Boiling Point：

300.2±15.0 °C at 760 mmHg

Flash Point：

135.4±20.4 °C

Refractive Index：

1.497

Water Solubility：

H2O: 1g/6ml

Storage Conditions：

Store at 0°C

Vapor Pressure：

0mmHg at 25°C

Toxicity：

Oral-rat LD50: 3000 mg/kg; Subcutaneous-mouse LD50:5310 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Packing level：

Hazard category：

IRRITANT

Transport codes：

UN 1993 3/PG 2

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-37/39

RTECS Number：

GU8400000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Toxicity

Toxicity class：

moderately toxic

Tranexamic acid Use and Manufacturing

Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.

Drug Function and Efficacy

Tranexamic acid competitively inhibits the adsorption of plasminogen on fibrin, reduces the generation of plasmin, and thus inhibits the degradation of fibrin and prevents bleeding.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Tranexamic acid tablets
Ingredients	The main ingredient is tranexamic acid.
Indication	1. It is incompatible with thrombolytic agents such as penicillin or urokinase; 2. The combination of oral contraceptives, estrogen or prothrombin complex concentrates with this product may increase the risk of thrombosis.
Specifications	0.5 g

Tranexamic Acid Injection
Ingredients	Tranexamic acid
Indication	The combined use of oral contraceptives, estrogens or prothrombin complex concentrates with this product may increase the risk of thrombosis.
Specifications	2ml:0.1g

Tranexamic Acid Injection
Ingredients	Tranexamic acid
Indication	The combined use of oral contraceptives, estrogens or prothrombin complex concentrates with this product may increase the risk of thrombosis.
Specifications	2 ml: 0.2 g

See More Related Drugs

Registered Holders

MALLADI DRUGS AND PHARMACEUTICALS LTD

United States
Active
Yantai Valiant Pharmaceutical Co.,Ltd.

Japan
Active
Cheer Fine Pharmaceutical Co.,Ltd.

Japan
Active

See More Registered Holders

Recommended Suppliers of Tranexamic acid

Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

99% Cosmetic Grade Tranexamic Acid CAS 1197-18-8 White Raw Power With Best Price

CAS No.: 1197-18-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
ECHEMI Chemical Contact Supplier

CN
8 YRS

Business licensed

Distributor Supplier of Resin,Coating&Ink,Adhesive,Polyurethane,Home&Personal Care,Plastic & Rubber

Tranexamic acid Echemi Specialties

CAS No.: 1197-18-8

Inquiry
Mecacol technology wuxi Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Professional Cosmetic Ingridients Supplier,Ethyl ascorbic acid,Piroctone Olamine,Ferulic Acid,Kojic acid dipalmitate,Magnesium ascorbyl phosphate,Tranexamic acid,DL-Mandelic Acid,Alkyl Polyglycosides ,Cetearyl Glucoside and cetearyl alcohol

TA

CAS No.: 1197-18-8

Inquiry
Wuhan BJM Pharm Inc. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Octocrylene,Etocrilene,Ethylhexyl Triazone,Tris Base,DL-Homocysteinethiolactone hydrochloride,Thiodiglycolic anhydride,Tris HCL,DHHB,VCE

Tranexamic Acid 1197-18-8

CAS No.: 1197-18-8

Grade: Cosmetics Grade

Content: 99%

Inquiry
Hangzhou Deli - raw material and API Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of Drospirenone,Tretinoin,Tranexamic acid,Tretinoin,Desogestrel,Diosmin,Isotretinoin,Ambroxol hcl,Brimonidine Tartrate,Bromhexine hcl,Isotretinoin,Dydrogesterone,Sulfacetamide sodium,Minoxidil,Pentosan Polysulfate Sodium,Tosyl chloride,4-Nitrobenzaldehyde,Bakuchiol,D-Chiro Inositol

Tranexamic Acid

CAS No.: 1197-18-8

Grade: Medical grade

Content: 99%

Inquiry