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Piperazine, phosphate (1:?)

Piperazine, phosphate (1:?) structure

CAS No:
1951-97-9
Formula:
C4H10N2.xH3O4P
Chemical Name:
Piperazine, phosphate (1:?)
Synonyms:
Piperazine,phosphate (1:?);Piperazine,phosphate
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

Piperazine, phosphate (1:?) Basic Attributes

Molecular Weight：

202.15

Exact Mass：

184.061295

EC Number：

217-775-8

UNII：

P7S1V82385

HScode：

2933599090

Characteristics

PSA：

126.31000

XLogP3：

4.50130

Density：

1.92g/cm3

Melting Point：

106ºC

Boiling Point：

468.9ºC at 760 mmHg

Flash Point：

237.4ºC

Safety Information

hazard class code：

36/37/38

safety instructions：

26-37/39

Marks：

GHS Classification：

Not Classified| |Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P272, P273, P280, P281, P285, P302+P352, P304+P341, P305+P351+P338, P308+P313, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P405, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P285, P302+P352, P304+P341, P305+P351+P338, P307+P311, P308+P313, P314, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P405, and P501

Drug Information

MeSH：

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)

MeSH Entry Terms：

1,4 Diazacyclohexane

Computed Properties

Molecular Weight:184.13
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Exact Mass:184.06129390
Monoisotopic Mass:184.06129390
Topological Polar Surface Area:102
Heavy Atom Count:11
Complexity:76.3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Piperazine has the effect of paralyzing the muscles of roundworms. Its mechanism may be that piperazine exerts an anticholinergic effect at the neuromuscular junction of the worm body, blocks the excitatory effect of acetylcholine on the muscles of roundworms, or changes the permeability of the muscle cell membrane of the worm body to ions, affecting the transmission of nerve impulses; it can also inhibit the production of succinate, reduce the supply of energy, block the neuromuscular junction, and prevent the impulse from being delivered. As a result, the roundworms are detached from the parasitic site and excreted from the body with intestinal peristalsis. Ascaris does not show excitatory effects before paralysis, so it is safer to use this product. This product has no effect on roundworm larvae, and its effect on the muscles of mammals is also very weak. Its mechanism of action on pinworms is not yet clear.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Piperazine Phosphate Tablets
Ingredients	Piperazine phosphate.
Indication	1. This product may cause convulsions when used together with chlorpromazine, so it should be avoided. 2. It has an antagonistic effect when used together with pyrantel. 3. After animals take piperazine and nitrite orally, piperazine can be converted into nitroso compounds in the stomach to form N,N-dinitropiperazine or N-mononitropiperazine, both of which are carcinogens for animals. After healthy non-smoking men were given piperazine syrup (containing 480 mg) orally on an empty stomach, a considerable amount of N-mononitropiperazine was also detected in their gastric juice and excreted in the urine, but N,N-dinitropiperazine was not found.
Specifications	0.2g
Manufacturer	Chongqing Dikang Changjiang Pharmaceutical Co., Ltd.

Piperazine Phosphate Tablets
Ingredients	Piperazine phosphate.
Indication	1. This product may cause convulsions when used together with chlorpromazine, so it should be avoided. 2. It has an antagonistic effect when used together with pyrantel. 3. After animals take piperazine and nitrite orally, piperazine can be converted into nitroso compounds in the stomach to form N,N-dinitropiperazine or N-mononitropiperazine, both of which are carcinogens for animals. After healthy non-smoking men were given piperazine syrup (containing 480 mg) orally on an empty stomach, a considerable amount of N-mononitropiperazine was also detected in their gastric juice and excreted in the urine, but N,N-dinitropiperazine was not found.
Specifications	0.2g
Manufacturer	Kaifeng Pharmaceutical (GROUP) Co., Ltd.

Piperazine Phosphate Tablets
Ingredients	Piperazine phosphate.
Indication	1. This product may cause convulsions when used together with chlorpromazine, so it should be avoided. 2. It has an antagonistic effect when used together with pyrantel. 3. After animals take piperazine and nitrite orally, piperazine can be converted into nitroso compounds in the stomach to form N,N-dinitropiperazine or N-mononitropiperazine, both of which are carcinogens for animals. After healthy non-smoking men were given piperazine syrup (containing 480 mg) orally on an empty stomach, a considerable amount of N-mononitropiperazine was also detected in their gastric juice and excreted in the urine, but N,N-dinitropiperazine was not found.
Specifications	0.5g
Manufacturer	Qinghai Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Chongqing Qingyang Pharmaceutical Co., Ltd.

China
Active
Hunan Xiangyikang Pharmaceutical Co., Ltd.

China
Active
Jiangsu Hi-stone Pharmaceutical Co., Ltd.

China
Active

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CAS No.: 1951-97-9

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Piperazine Phosphate1951-97-9

CAS No.: 1951-97-9

Grade: Pharmaceutical Grade

Content: 99%

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Guide of Piperazine, phosphate (1:?)

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

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