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Halofantrine hydrochloride

Halofantrine hydrochloride structure

CAS No:
36167-63-2
Formula:
C26H30Cl2F3NO.ClH
Chemical Name:
Halofantrine hydrochloride
Synonyms:
Halfan;D02485;Halfan (tn);Halofantrine hydrochloride (usan);Halofantarine HCL;Halfan, 1,3-Dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride;1,3-dichloro-alpha-[2-(dibutylamino)ethyl]-6- (trifluoromethyl)-9-phenathrenemethanol hydrochloride;halofantrine hydrochloride
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound[1][2].

White Solid

Halofantrine hydrochloride Basic Attributes

Molecular Weight：

536.89

Exact Mass：

535.142334

EC Number：

252-895-4

Color/Form：

white to off-white

Characteristics

PSA：

23.5

XLogP3：

9.44630

Appearance：

white to off-white

Density：

1.244g/cm3

Melting Point：

93-96°; mp 203-204°

Boiling Point：

596.2ºC at 760mmHg

Flash Point：

314.4ºC

Water Solubility：

DMSO: >10mg/mL

Storage Conditions：

2-8°C

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

SF7790000

Precautionary statement(s)：

P273, P501

Hazard Statements：

H413

Halofantrine hydrochloride Use and Manufacturing

Antimalarial.

halofantrine, a drug that is effective against chloroquine-resistant malaria and is now being evaluated in Africa.

Computed Properties

Molecular Weight:536.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:535.142332
Monoisotopic Mass:535.142332
Topological Polar Surface Area:23.5
Heavy Atom Count:34
Complexity:584
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of Halofantrine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Latest News
Learn More Other Chemicals

Halofantrine hydrochloride

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