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CINCHONINE HYDROCHLORIDE

CINCHONINE HYDROCHLORIDE structure

CAS No:
5949-11-1
Formula:
C19H23ClN2O
Chemical Name:
CINCHONINE HYDROCHLORIDE
Synonyms:
Cinchonine monohydro;(S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride;cinchonine,monohydrochloride;monohydrochloride,(9s)-cinchonan-9-o;CINCHODININE DIHYDROCHLORIDE;CINCHONINE HYDROCHLORIDE;(+)-CINCHONINE HYDROCHLORIDE N-HYDRATE;CINCHONINE HYDROCHLORIDE N-HYDRATE
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Cinchonine hydrochloride not only possesses the required solubility and bioavailability criteria for pharmaceutical formulations while retaining desired therapeutic properties, but is also very stable in solution, which facilitates the preparation of aqueous formulations, especially injections.

CINCHONINE HYDROCHLORIDE Basic Attributes

Molecular Weight：

330.85

Exact Mass：

330.149902

EC Number：

621-239-2

UNII：

4PSQ7YHS4T

Characteristics

PSA：

36.36000

XLogP3：

3.90450

Melting Point：

208-218 °C(lit.)

Boiling Point：

464.5ºC at 760 mmHg

Critical Temperature & Pressure：

under inert gas (nitrogen or Argon) at 2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

Xn,Xi

safety instructions：

36/37-36-26

RTECS Number：

GD2962020

Marks：

Xn,Xi

Hazard Statements：

20/21/22-36/37/38

RIDADR：

1544

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

CINCHONINE HYDROCHLORIDE Use and Manufacturing

Cinchonine hydrochloride can be used as an inhibitory substance for the phenomenon of "multidrug resistance" (MDR). In particular, cinchonine hydrochloride compositions are useful in the treatment of cancer-related diseases with MDR phenomena.

Computed Properties

Molecular Weight:330.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:330.1498911
Monoisotopic Mass:330.1498911
Topological Polar Surface Area:36.4
Heavy Atom Count:23
Complexity:412
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes