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Cefmetazole sodium

Cefmetazole sodium structure

CAS No:
56796-39-5
Formula:
C15H17N7O5S3.Na
Chemical Name:
Cefmetazole sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[2-[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1),(6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt,(6R-cis)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt,(6R,7S)-;CS-1170 sodium salt;Sodium cefmetazole;Cefmetazone;Cefmetazole-Na;Cefmetazole sodium;Metazol;Zefazone;Cefmetazon;Metafar
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefmetazole sodium is a semisynthetic cephamycin antibiotic. Target: AntibacterialCefmetazole sodium has a broad spectrum of activity comparable to that of the second-generation cephalosporins, covering gram-positive, gram-negative, and anaerobic bacteria. Unlike the second-generation cephalosporins, cephamycins such as cefmetazole are usually active against Bacteroides fragilis. Cefmetazole is also active against beta-lactamase-producing organisms that are resistant to first-generation

Cefmetazole sodium Basic Attributes

Molecular Weight：

493.52

Exact Mass：

493.027283

EC Number：

1308068-626-2

Characteristics

PSA：

242

XLogP3：

-1.73422

Appearance：

White solid

Density：

1.75 g/cm3

Water Solubility：

H2O: soluble 50mg/mL

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LD50: 3204 mg/kg; Oral-Mouse LD50: 3228 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, sodium oxide fumes

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

26-36

RTECS Number：

XI0372200

Marks：

Xn,Xi

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P261-P280-P305 + P351 + P338-P342 + P311

Hazard Statements：

H315-H317-H319-H334-H335

Toxicity

Toxicity class：

moderately toxic

Cefmetazole sodium Use and Manufacturing

Methods of Manufacturing

Take 40g of the 7-methoxycephalosporin nucleus, added with 200ml of ethyl acetate and 200ml N'N-dimethylformamide, dissolved, at 0 deg. C added with 22g cyanomethylacetyl potassium, reaction for 30min, added with water and glacial acetic acid to adjust the pH to 2, extraction, the ethyl acetate layer was added 6percent aqueous sodium bicarbonate, washed once with an aqueous solution of 20g of alumina to decolorize, filtered, and the aqueous solution was added 20g methyl isobutyl ketone and 20percent phosphoric acid to adjust the pH2, cooled to 5 deg. C, crystallization 5h, filter cake at 40 deg. C under vacuum drying 6h, obtained 32g cefmetazole sodium, identified above by HPLC purity of 99 percent, the biggest single hetero less than 0.2percent, less than 0.5percent of total miscellaneous, color grade No. 2.

Uses

Semi-synthetic antibiotic derived from Cephamycin. Antibacterial

Drug Function and Efficacy

None

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefmetazole Sodium for Injection
Ingredients	Cefmetazole Sodium
Indication	None
Specifications	1.0g (calculated as C15H17N7O5S3)

Cefmetazole Sodium for Injection
Ingredients	Cefmetazole Sodium
Indication	None
Specifications	0.5g
Manufacturer	Fuan Pharmaceutical Group Qingyutang Pharmaceutical Co., Ltd.

Cefmetazole Sodium for Injection
Ingredients	Cefmetazole Sodium
Indication	None
Specifications	2.0 g

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Registered Holders

Zhejiang Dongbang Pharmaceutical Co., Ltd.

China
Active
Ppd Pharmaceutical Development (Beijing) Co., Ltd.

China
Active
Fujian Fukang Pharmaceutical Co., Ltd.

China
Active

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