Bepotastine besilate
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Bepotastine besilate
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CAS No:
190786-44-8
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Formula:
C21H25ClN2O3.C6H6O3S
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Chemical Name:
Bepotastine besilate
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Synonyms:
1-Piperidinebutanoic acid,4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-,benzenesulfonate (1:1);1-Piperidinebutanoic acid,4-[(4-chlorophenyl)-2-pyridinylmethoxy]-,(S)-,monobenzenesulfonate;1-Piperidinebutanoic acid,4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-,monobenzenesulfonate;Bepotastine besilate;Talion;Bepotastine benzenesulfonate salt;BB;Bepreve;TAU 284;Bepotastine besylate;Bepotastine benzenesulfonate;(S)-4-[4-(4-chlorophenyl-2-pyridylmethoxy)piperidinyl]butyric acid benzenesulfonate;Tarion;Betatastine
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CAS No:
Description
Off-White to Light Beige SolidChEBI: An organosulfonate salt obtained by combining equimolar amounts of bepotastine and benzenesulfonic acid. A topical, selective and non-sedating histamine (H1) receptor antagonist used for treatment of itching associated with allergic co junctivitis.Betotastine was introduced in Japan for the treatment of allergic rhinitis. This structurally-related derivative of chlorpheniramine and ebastine is prepared by condensation of optically-resolved 4-[1-(4-chlorop
Bepotastine besylate is an organosulfonate salt obtained by combining equimolar amounts of bepotastine and benzenesulfonic acid. A topical, selective and non-sedating histamine (H1) receptor antagonist used for treatment of itching associated with allergic conjunctivitis. It has a role as a H1-receptor antagonist and an anti-allergic agent. It contains a bepotastine(1+).
Characteristics
125
6.12220
Brown Viscous liquid
161-163°
546.8ºC at 760 mmHg
284.5ºC
-196°C
8.63E-13mmHg at 25°C
D20 +6.0° (c = 5 in methanol)
Drug Information
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)
bepotastine besilate
Bepotastine besilate Use and Manufacturing
Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:547.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:546.1591356
Monoisotopic Mass:546.1591356
Topological Polar Surface Area:125
Heavy Atom Count:37
Complexity:632
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Anti-allergic
Registered Holders
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Chongqing Shengkai Pharmaceutical Co., Ltd.
Active
China
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Gansu Haotian PharmaTech Co., Ltd.
Active
China
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Aurisco Pharmaceutical Co., Ltd.
Active
China
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