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Carmofur

Carmofur structure

CAS No:
61422-45-5
Formula:
C11H16FN3O3
Chemical Name:
Carmofur
Synonyms:
1(2H)-Pyrimidinecarboxamide,5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-;5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinecarboxamide;1-(Hexylcarbamoyl)-5-fluorouracil;1-(n-Hexylcarbamoyl)-5-fluorouracil;HCFU;1-(Hexylcarbamyl)-5-fluorouracil;Carmofur;Mifurol;Yamaful
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent. Target: Nucleoside antimetabolite/analogCarmofur, which is used in the clinic to treat colorectal cancers, is a potent AC inhibitor and that this property is essential to its anti-proliferative effects. Carmofur inhibited AC activity with a median effective concentration (IC50) of 29 ± 5 nM (mean ± standard error of the mean, s.e.m.; n = 4), whereas 5-FU had no such effect (IC50>1 mM). systemic a

Carmofur is an organohalogen compound and a member of pyrimidines.|Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.|Carmofur is an antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil. (NCI)

Carmofur Basic Attributes

Molecular Weight：

257.26

Exact Mass：

257.26

EC Number：

1312995-182-4

UNII：

HA82M3RAB2

NSC Number：

758963

DSSTox ID：

DTXSID2045941

NCI Thesaurus Code：

C955

ATC Code：

L - Antineoplastic and immunomodulating agents

HScode：

2933599090

Characteristics

PSA：

78.5

XLogP3：

2.6

Appearance：

white to off-white

Density：

1.3±0.1 g/cm3

Melting Point：

110-111 °C

Refractive Index：

1.525

Water Solubility：

DMSO: >15mg/mL

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LD50: 268 mg/kg; Oral-Mouse LD50: 1129 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides and fluoride fumes

Safety Information

Packing level：

Ⅱ

Hazard category：

6.1

Transport codes：

UN 2811 6.1 / PGII

wgk germany：

hazard class code：

60-61-25

safety instructions：

RTECS Number：

UV7714000

Marks：

Xi,T

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

Hazard note：

Irritant

Precautionary statement(s)：

P281-P301 + P310

Hazard Statements：

H301-H361

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

1-hexylcarbamoyl-5-fluorouracil

Carmofur Use and Manufacturing

antineoplastic

Computed Properties

Molecular Weight:257.26
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:257.11756954
Monoisotopic Mass:257.11756954
Topological Polar Surface Area:78.5
Heavy Atom Count:18
Complexity:382
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a derivative of fluorouracil. It is rapidly absorbed orally and slowly releases fluorouracil in the body, interfering with or blocking the synthesis of DNA, RNA and protein to exert an anti-tumor effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

Shandong Anxin Pharmaceutical Co., Ltd.

China
Active
Hubei Gedian Humanwell Pharmaceutical Co., Ltd.

China
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