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Bisantrene

Bisantrene structure

CAS No:
78186-34-2
Formula:
C22H22N8
Chemical Name:
Bisantrene
Synonyms:
9,10-Anthracenedicarboxaldehyde,9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone];9,10-Anthracenedicarboxaldehyde,bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone];Bisantrene
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases.

Bisantrene is a hydrazone resulting from the formal condensation of both of the aldehyde groups of anthracene-9,10-dicarbaldehyde with 2-hydrazinyl-4,5-dihydro-1H-imidazole. It has a role as an antineoplastic agent. It is a hydrazone, a member of imidazolidines and a member of anthracenes.

Bisantrene Basic Attributes

Molecular Weight：

398.46

Exact Mass：

398.46

HScode：

2933290090

Characteristics

PSA：

97.56000

XLogP3：

2.06900

Density：

1.41g/cm3

Boiling Point：

646.3ºC at 760 mmHg

Flash Point：

344.7ºC

Refractive Index：

1.757

Water Solubility：

deionized water: soluble8mg/mL

Storage Conditions：

room temp

Toxicity：

Unnamed-Mouse LD50: 245 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

22-50/53

safety instructions：

60-61

Marks：

Xn,N

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Precautionary statement(s)：

P273

Hazard Statements：

H302-H400

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

MeSH Entry Terms：

9,10-anthracenedicarboxaldehyde bis(4,5-dihydro-1H-imidazol-2-yl)hydrazone

Bisantrene Use and Manufacturing

Methods of Manufacturing

9, 10-anthracene dialdehyde reacts with 2-hydrazino-2-imidazoline dihydrochloride to obtain Bishengqun dihydrochloride.

Uses

Anthracycline cell growth inhibitor, used for anti-tumor. It is effective for malignant lymphoma, melanoma, acute leukemia, ovarian cancer and kidney cancer.

Computed Properties

Molecular Weight:398.5
XLogP3:1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:398.19674274
Monoisotopic Mass:398.19674274
Topological Polar Surface Area:97.6
Heavy Atom Count:30
Complexity:630
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes