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Norcantharidin

Norcantharidin structure

CAS No:
29745-04-8
Formula:
C8H8O4
Chemical Name:
Norcantharidin
Synonyms:
4,7-Epoxyisobenzofuran-1,3-dione,hexahydro-,(3aR,4S,7R,7aS)-rel-;7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride,exo-;4,7-Epoxyisobenzofuran-1,3-dione,hexahydro-,(3aα,4β,7β,7aα)-;rel-(3aR,4S,7R,7aS)-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione;7-Oxabicyclo[2.2.1]heptane-exo-cis-2,3-dicarboxylic anhydride;Norcantharidin;NSC 59023;(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione;Isocantharidin;Demethylcantharidin;exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid anhydride;167933-28-0;201815-15-8;204204-47-7;433956-00-4;1446101-67-2;1474031-41-8
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

(±)-Norcantharidin ((±)-NCTD) is a compound possessing anti-angiogenetic activity with potential use in anti-cancertherapy. (±)-Norcantharidin could prevent tumorigenesis by inhibiting cell proliferation, inducing apoptosis and the cell cycle arrest, and anti-angiogenic effects[1].

Norcantharidin Basic Attributes

Molecular Weight：

168.15

Exact Mass：

168.15

BRN：

84287

EC Number：

-0

HScode：

2932999099

Characteristics

PSA：

52.60000

XLogP3：

-0.85

Appearance：

solid

Density：

1.5±0.1 g/cm3

Melting Point：

116-117 °C

Boiling Point：

362.5±35.0 °C at 760 mmHg

Flash Point：

167.0±26.0 °C

Refractive Index：

1.550

Water Solubility：

Hydrolyzes in water.

Toxicity：

Peritoneal-mouse LD50: 4 mg/kg

Flammability characteristics：

Flammable, spicy and irritating smoke emitted from the fire

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

RN8400000

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

most toxic

Norcantharidin Use and Manufacturing

Has treatments for liver cancer, breast cancer, lung cancer, stomach cancer, esophageal cancer, colon cancer, skin cancer and other cancers

Computed Properties

Molecular Weight:168.15
XLogP3:-0.1
Hydrogen Bond Acceptor Count:4
Exact Mass:168.04225873
Monoisotopic Mass:168.04225873
Topological Polar Surface Area:52.6
Heavy Atom Count:12
Complexity:246
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes