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Haloperidol decanoate

Haloperidol decanoate structure

CAS No:
74050-97-8
Formula:
C31H41ClFNO3
Chemical Name:
Haloperidol decanoate
Synonyms:
Decanoic acid,4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl ester;Haloperidol decanoate;KD 136;Haldol decanoate;Neoperidole;Halomonth;KD 16;R 13762;77129-05-6
Categories:
Analytical Chemistry > Standard

Description

White or almost white powder

Haloperidol decanoate is an organic molecular entity.|Haloperidol Decanoate is the decanoate ester of haloperidol, a phenylbutylpiperadine derivative with antipsychotic, neuroleptic and antiemetic effects. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain leading to anti-delusionary and anti-hallucinogenic effects. The antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) account for its antiemetic activity.

Haloperidol decanoate Basic Attributes

Molecular Weight：

530.1135432

Exact Mass：

530.11

EC Number：

277-679-7

UNII：

AC20PJ4101

DSSTox ID：

DTXSID50224951

NCI Thesaurus Code：

C47998

HScode：

2933399090

Characteristics

PSA：

46.61000

XLogP3：

8.05510

Density：

1.14 g/cm3

Melting Point：

326.1ºC

Boiling Point：

615.5ºC at 760 mmHg

Flash Point：

326.1ºC

Refractive Index：

1.554

Water Solubility：

Practically insoluble in water, very soluble in ethanol (96 per cent), in methanol and in methylene chloride.

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P273, P280, P281, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P321, P322, P330, P363, P391, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (70%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P301+P312, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 11 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

MeSH Entry Terms：

haloperidol decanoate

Haloperidol decanoate Use and Manufacturing

Uses

Haloperidol Decanoate is an antipsychotic and antidyskinetic agent.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:530.1
XLogP3:7.9
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:16
Exact Mass:529.2759000
Monoisotopic Mass:529.2759000
Topological Polar Surface Area:46.6
Heavy Atom Count:37
Complexity:665
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes