 Home > Encyclopedia > Estradiol hemihydrate

Estradiol hemihydrate

Estradiol hemihydrate structure

CAS No:
35380-71-3
Formula:
C18H24O2.¹/2H2O
Chemical Name:
Estradiol hemihydrate
Synonyms:
Estra-1,3,5(10)-triene-3,17-diol (17β)-,hydrate (2:1);Estradiol hemihydrate;β-Estradiol semihydrate;β-Estradiol hemihydrate;Estrasorb
Categories:
Analytical Chemistry > Standard

Description

Estradiol Hemihydrate is the hemihydrate form of estradiol, the most potent, naturally produced estrogen. Estradiol hemihydrate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics.|The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

Estradiol hemihydrate Basic Attributes

Molecular Weight：

290.4

Exact Mass：

562.365845

EC Number：

200-023-8

UNII：

CXY7B3Q98Z

NCI Thesaurus Code：

C47992

ATC Code：

H01CC54

HScode：

2937230000

Characteristics

PSA：

49.69000

XLogP3：

3.54490

Boiling Point：

445.9ºC at 760mmHg

Flash Point：

209.6ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

60-63-40-64

safety instructions：

53-36/37-45

Marks：

Precautionary statement(s)：

P201-P263-P281-P308 + P313

Hazard Statements：

H351-H360Fd-H362

GHS Classification：

|Danger|H302 (21.43%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 84 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Ryeqo is indicated for treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age.

MeSH：

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. (See all compounds classified as Estrogens.)

MeSH Entry Terms：

17 beta Estradiol

Estradiol hemihydrate Use and Manufacturing

Use Classification：

Human drugs -> Rare disease (orphan)|Human drugs -> Ryeqo -> EMA Drug Category|Pituitary and hypothalamic hormones and analogues -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:562.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Exact Mass:562.36582469
Monoisotopic Mass:562.36582469
Topological Polar Surface Area:81.9
Heavy Atom Count:41
Complexity:382
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Recommended Suppliers of Estradiol hemihydrate

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Estradiol hemihydrate CAS35380-71-3 White or opalescent leaf or acicular crystals

CAS No.: 35380-71-3

Grade: Ingredients

Content: 99%

Inquiry
Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

17-Beta Estradiol Hemihydrate API Active Pharmaceutical Ingredient For Hormone Preparation CAS 35380-71-3

CAS No.: 35380-71-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry