Estradiol hemihydrate
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Estradiol hemihydrate
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CAS No:
35380-71-3
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Formula:
C18H24O2.1/2H2O
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Chemical Name:
Estradiol hemihydrate
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Synonyms:
Estra-1,3,5(10)-triene-3,17-diol (17β)-,hydrate (2:1);Estradiol hemihydrate;β-Estradiol semihydrate;β-Estradiol hemihydrate;Estrasorb
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CAS No:
Description
Estradiol Hemihydrate is the hemihydrate form of estradiol, the most potent, naturally produced estrogen. Estradiol hemihydrate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics.|The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Estradiol hemihydrate Basic Attributes
290.4
562.365845
200-023-8
CXY7B3Q98Z
C47992
H01CC54
2937230000
Safety Information
NONH for all modes of transport
3
60-63-40-64
53-36/37-45
T
P201-P263-P281-P308 + P313
H351-H360Fd-H362
|Danger|H302 (21.43%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 84 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Ryeqo is indicated for treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. (See all compounds classified as Estrogens.)
17 beta Estradiol
Estradiol hemihydrate Use and Manufacturing
Human drugs -> Rare disease (orphan)|Human drugs -> Ryeqo -> EMA Drug Category|Pituitary and hypothalamic hormones and analogues -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:562.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Exact Mass:562.36582469
Monoisotopic Mass:562.36582469
Topological Polar Surface Area:81.9
Heavy Atom Count:41
Complexity:382
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Recommended Suppliers of Estradiol hemihydrate
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CN
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Business licensedTrader Supplier of Chemical,Intermediate,5-amino-1mq,SLU-PP332,Tirzepatide,Peptide,KY19382,5-deazaflavin,Dihexa,Urolithin AInquiryCAS No.: 35380-71-3Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
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Business licensedTrader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional SupplementsInquiryUnit Price: nullnull /null nullCAS No.: 35380-71-3Grade: Pharmaceutical GradeContent: 99%
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