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Hydroxysafflor yellow A

Hydroxysafflor yellow A structure

CAS No:
78281-02-4
Formula:
C27H32O16
Chemical Name:
Hydroxysafflor yellow A
Synonyms:
2,5-Cyclohexadien-1-one,2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-;2,5-Cyclohexadien-1-one,2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-;2,4-Di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-2,5-cyclohexadien-1-one;Safflomin A;Hydroxysafflor yellow A;HSYA;146087-19-6;664361-78-8
Categories:
Analytical Chemistry > Standard

Description

Hydroxysafflor yellow A is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L., possesses anti-tumor activity. IC50 value:Target: in vitro: HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. We further showed that HYSA inhibited LPS-induced upregulation of TLR-4 expression as well as the activation of Rac1/Akt pathway [1

Hydroxysafflor yellow A is a C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius). It has a role as an anti-inflammatory agent, an antioxidant, a platelet aggregation inhibitor, an antineoplastic agent, a radical scavenger, an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor, a neuroprotective agent and a plant metabolite. It is a C-glycosyl compound, a member of phenols, an enone and an enol.

Hydroxysafflor yellow A Basic Attributes

Molecular Weight：

612.53338

Exact Mass：

612.53

HScode：

29389090

Characteristics

PSA：

295.36000

XLogP3：

2.98

Density：

1.9±0.1 g/cm3

Melting Point：

184-186 °C

Boiling Point：

1015.8±65.0 °C at 760 mmHg

Flash Point：

334.0±27.8 °C

Refractive Index：

1.797

Safety Information

safety instructions：

24/25

Drug Information

MeSH Entry Terms：

hydroxy safflower yellow pigment A

Computed Properties

Molecular Weight:612.5
XLogP3:-3.5
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:6
Exact Mass:612.16903493
Monoisotopic Mass:612.16903493
Topological Polar Surface Area:295
Heavy Atom Count:43
Complexity:1160
Defined Atom Stereocenter Count:10
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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