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Isoforskolin

Isoforskolin structure

CAS No:
64657-21-2
Formula:
C22H34O7
Chemical Name:
Isoforskolin
Synonyms:
1H-Naphtho[2,1-b]pyran-1-one,6-(acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-;1H-Naphtho[2,1-b]pyran-1-one,6-(acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-,[3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-;(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(Acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one;Coleonol B;Isoforskolin;Excolabdone C;(1α,5α,6β,7β)-6-(Acetyloxy)-8,13-epoxy-1,7,9-trihydroxylabd-14-en-11-one;6β-Acetoxy-8,13-epoxy-1α,7β,9α-trihydroxylabd-14-en-11-one;67921-05-5
Categories:
Natural Products > Terpenes

Description

Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis[1].

Isoforskolin Basic Attributes

Molecular Weight：

410.5

Exact Mass：

410.50

EC Number：

613-649-5

DSSTox ID：

DTXSID20433992

Characteristics

PSA：

113.29000

XLogP3：

3.40

Density：

1.2±0.1 g/cm3

Melting Point：

220-222 °C @ Solvent: Chloroform, Methanol

Boiling Point：

524.5±50.0 °C at 760 mmHg

Flash Point：

173.6±23.6 °C

Refractive Index：

1.552

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

Marks：

GHS Classification：

Not Classified

Computed Properties

Molecular Weight:410.5
XLogP3:1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:410.23045342
Monoisotopic Mass:410.23045342
Topological Polar Surface Area:113
Heavy Atom Count:29
Complexity:747
Undefined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Isoforskolin

Description
Basic Attributes
Characteristics
Safety Information
Computed Properties
Learn More Other Chemicals

Isoforskolin

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