2,3-Difluorobenzyl alcohol

Clear colorless to pale brown liquid

2,3-difluorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by fluoro groups at positions 2 and 3 respectively. It is an organofluorine compound and a member of benzyl alcohols.

Step 1 (MW-Si):Sodium borohydride (5.3 g, 140.84 mmol) was slowly added in 3 equal portions (over 25 mm)to a solution of 2, 3-difluorobenzaldehyde (20 g, 140.84 mmol) in methanol (200 mL) at 0°C.Due to the exothermic reaction the temperature raised up to ‘50°C. The reaction mixturewas stirred for 1 h and the solvent was evaporated under reduced pressure. Ethyl acetateand thereafter saturated ammonium chloride solution was added. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layer was washed successively with water, brine; dried over anhydrous sodium sulfate and concentrated in vacuum to afford 20 g of MW-Si as a colorless liquid, further used withoutany purification.In a 5 ml quartz glass reaction tube, 0.1 mmol of

Molecular Weight:144.12
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:144.03867113
Monoisotopic Mass:144.03867113
Topological Polar Surface Area:20.2
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes