 Home > Encyclopedia > 4-Bromo-2-fluorobenzyl bromide

4-Bromo-2-fluorobenzyl bromide

4-Bromo-2-fluorobenzyl bromide structure

CAS No:
76283-09-5
Formula:
C7H5Br2F
Chemical Name:
4-Bromo-2-fluorobenzyl bromide
Synonyms:
Benzene,4-bromo-1-(bromomethyl)-2-fluoro-;4-Bromo-1-(bromomethyl)-2-fluorobenzene;2-Fluoro-4-bromobenzyl bromide;4-Bromo-2-fluorobenzyl bromide;α,4-Dibromo-2-fluorotoluene;4-Bromo-1-bromomethyl-2-fluorobenzene;4-Bromo-2-fluoro-(bromomethyl)benzene
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

Request for Quotation

Description

white to light yellow crystal powder

4-Bromo-2-fluorobenzyl bromide Basic Attributes

Molecular Weight：

267.92

Exact Mass：

267.92

BRN：

4307676

EC Number：

278-412-7

UNII：

0Z26XYC1JY

DSSTox ID：

DTXSID1057822

HScode：

2903999090

Characteristics

PSA：

XLogP3：

3.3

Appearance：

White to off-white Low Melting Solid

Density：

1.9±0.1 g/cm3

Melting Point：

33-36 °C(lit.)

Boiling Point：

126 °C (19 mmHg)

Flash Point：

126°C/9mm

Refractive Index：

1.583

Storage Conditions：

Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

UN 2923 8/PG 3

wgk germany：

hazard class code：

22-34-52/53-20/21/22

safety instructions：

26-36/37/39-45-61

Marks：

Hazard note：

Corrosive/Lachrymatory

Stability/Shelf Life：

Stable under normal shipping and handling conditions.

Precautionary statement(s)：

P280-P301 + P310-P305 + P351 + P338-P310

Hazard Statements：

H301-H314

GHS Classification：

|Danger|H301 (85.11%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P280, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P405, and P501|Aggregated GHS information provided by 47 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-Bromo-2-fluorobenzyl bromide Use and Manufacturing

Methods of Manufacturing

4-bromo-1-(bromomethyl)-2-fluorobenzene [0268] 1-Bromo-2-fluoro-4-methylbenzene (1 g, 5.04 mmol) was added to the solution after dissolving NBS (1.07 g, 6.05 mmol) and AIBN (83 mg, 0.50 mmol) in CCl4 And the mixture was refluxed at 100 deg C for 13 hours. After the reaction was completed, the reaction mixture was cooled at room temperature, and the resulting solid was filtered. After the extraction with CCl4 and water more than 2 times, the organic layer was dried over anhydrous to remove excess water, then concentrated under reduced pressure 4-Bromo-1- (bromomethyl) -2-fluorobenzene (1.2 g, 4.47 mmol) was obtained in 89percent yieldA mixture of 4-bromo-2-fiuoro-l-methylbenzene (available from Aldrich; 2.0 g, 10.58 mmol), N-bromosuccinimide (1.88 g, 10.58 mmol) and AIBN (87 mg, 0.53 mmol) in CCI4 (30 mL) was heated at reflux under nitrogen for 4 h. The reaction mixture was cooled to room temperature, 5percent aqueous NaThe above compound (7.00 g, 34.1 mmol) was dissolved into 48percent hydrobromic acid (35 mL), and the resultant was caused to react at 100° for 10 minutes. After the end of the reaction, the resultant was neutralized with potassium carbonate. Thereafier, extraction with ethyl acetate was carried out, and this extraction layer was washed with water and a saturated saline solution, then dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure to yield a compound (8.35 g, 91percent). 1H-NMR (CDC13): 4.46 (s, 2H, HnCH2), 7.25-7.29 (m, 3H, Ar).

Uses

Used in pharmaceutical synthesis

Computed Properties

Molecular Weight:267.92
XLogP3:3.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:267.87215
Monoisotopic Mass:265.87420
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Bromo-2-fluorobenzyl bromide

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

4-Bromo-2-fluorobenzyl bromide

CAS No.: 76283-09-5

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale 4-Bromo-2-fluorobenzyl bromide 99% high quality see COA KANBEI

CAS No.: 76283-09-5

Grade: Industrial Grade

Content: 99%

Inquiry

Latest News on 4-Bromo-2-fluorobenzyl bromide

Learn More Other Chemicals

Neodymium bromide (NdBr3)

13536-80-6
diallylnormorphinium bromide

69576-07-4
2,3-DICHLORO-6-(TRIFLUOROMETHYL)BENZYL BROMIDE

886501-99-1
1-Tetradecanaminium, N,N,N-triethyl-, bromide (1:1) Formula

18144-35-9
1-Butanaminium, N,N,N-tripropyl-, bromide (1:1) Formula

61175-77-7
1-Hexanaminium, N-butyl-2-ethyl-N,N-dimethyl-, bromide (1:1) Formula

93839-31-7
3-Bromo-4-fluorobenzoyl bromide Structure

78239-66-4
2-BROMOBENZYLZINC BROMIDE Structure

307496-27-1
What is 1-Dodecanaminium, N-(2-ethoxy-2-oxoethyl)-N,N-dimethyl-, bromide (1:1)

1794-75-8
What is Benzothiazolium, 3-(2-hydroxyethyl)-2-methyl-, bromide (1:1)

63123-34-2

Hot Searches: chlorfenapyr; formula sulphur dioxide; cefepime drug; phthalic acid; thiamine pyrophosphate; oxalic acid formula

Guide of 4-Bromo-2-fluorobenzyl bromide

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

4-Bromo-2-fluorobenzyl bromide

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.