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Lercanidipine hydrochloride

Lercanidipine hydrochloride structure

CAS No:
132866-11-6
Formula:
C36H41N3O6.ClH
Chemical Name:
Lercanidipine hydrochloride
Synonyms:
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester,hydrochloride (1:1);3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester,monohydrochloride;Lercanidipine hydrochloride;Carmen;Renovia;Cardiovasc;Lercaton;Vasodip;Zandip;Lercapin;Corifeo;Lerkamen;Lercan;Zanicor;Lerzam;Lercadip;Rec 15/2375;R 75;Lotensyl;Lervasc
Categories:
Biochemical Engineering > Chinese Herbs

Description

Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of car

Lercanidipine hydrochloride is a diarylmethane.

Lercanidipine hydrochloride Basic Attributes

Molecular Weight：

648.19

Exact Mass：

647.276184

EC Number：

1308068-626-2

DSSTox ID：

DTXSID3046665

Characteristics

PSA：

114

XLogP3：

8.13240

Appearance：

yellow

Melting Point：

175-177°C

Boiling Point：

712.5°C at 760 mmHg

Flash Point：

384.7ºC

Storage Conditions：

2-8°C

Vapor Pressure：

3.77E-20mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 2811

hazard class code：

safety instructions：

36/37-45

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (87.76%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P301+P312, P321, P330, P405, and P501|Aggregated GHS information provided by 49 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

MeSH Entry Terms：

Lercadip

Lercanidipine hydrochloride Use and Manufacturing

long-acting dihydropyridine calcium channel blocker, antihypertensive

Computed Properties

Molecular Weight:648.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:647.2762138
Monoisotopic Mass:647.2762138
Topological Polar Surface Area:114
Heavy Atom Count:46
Complexity:1090
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not described in detail

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lercanidipine Hydrochloride
Manufacturer	Chongqing Shenghuaxi Pharmaceutical. Co., Ltd.

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Registered Holders

Guangzhou Tosun Pharmaceutical Ltd

China
Active
Shenyang Tianbang Pharmaceutical Co., Ltd.

China
Active
Hinye Pharmaceutical Co., Ltd.

China
Active

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Guide of Lercanidipine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Lercanidipine hydrochloride

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