Disodium pamidronate pentahydrate
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Disodium pamidronate pentahydrate
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CAS No:
109552-15-0
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Formula:
C3H11NO7P2.5H2O.2Na
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Chemical Name:
Disodium pamidronate pentahydrate
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Synonyms:
Phosphonic acid,P,P′-(3-amino-1-hydroxypropylidene)bis-,sodium salt,hydrate (1:2:5);Phosphonic acid,(3-amino-1-hydroxypropylidene)bis-,disodium salt,pentahydrate;Disodium pamidronate pentahydrate
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CAS No:
Description
Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.
Pamidronate disodium is a 1,1-bis(phosphonic acid).|Pamidronate Disodium is the disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.|An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.
Disodium pamidronate pentahydrate Basic Attributes
279.03
369.01778760 g/mol
260-647-1
8742T8ZQZA
DTXSID5042667
C1345
2942000000
Safety Information
NONH for all modes of transport
SZ6522666
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P309+P311, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Drug: Pamidronatedisodium
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)
(3-amino-1-hydroxypropylidene)-1,1-biphosphonate
Disodium pamidronate pentahydrate Use and Manufacturing
For the treatment of hypercalcemia and osteoporosis
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:369.11
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:4
Exact Mass:369.01778760
Monoisotopic Mass:369.01778760
Topological Polar Surface Area:172
Heavy Atom Count:20
Complexity:238
Covalently-Bonded Unit Count:8
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
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Luzhou Kereide Pharmaceutical Co., Ltd.
Active
China
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Jiangsu Shenlong Pharmaceutical Co., Ltd.
Active
China
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Hebei Anjian Chengyi Pharmaceutical Technology Co., Ltd.
Active
China
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Disodium pamidronate pentahydrate
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