TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE
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TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE
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CAS No:
51805-45-9
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Formula:
C9H16ClO6P
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Chemical Name:
TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE
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Synonyms:
3,3',3''-PHOSPHINETRIYL-TRIPROPIONIC ACID HYDROCHLORIDE;3,3',3''-PHOSPHINIDYNE-TRIPROPIONIC ACID HYDROCHLORIDE;TCEP HCL;TCEP*HCL;TCEP, HYDROCHLORIDE;TRI(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE;TRIS(2-CARBOXYETHYL)PHOSPHINE, HCL;TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE
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CAS No:
Description
TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry[1][2][3][4].
TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE Basic Attributes
286.65
286.037292
1592732-453-0
H49AAM893K
DTXSID10370367
2915900090
Characteristics
112
white powder
1.4
177 °C
202°C c.c.
n20/D 1.367
soluble in water and methanol.
2-8°C
negligible
Relative vapour density (air = 1): 9.8
149.1 Ų [M-H]-
Safety Information
III
8
UN 3261 8/PG 2
2
36/38-36/37/38-34
26-37/39-36/37/39-27-45
C,Xi
Keep in a well-ventilated room. Store in an area without drain or sewer access. Separated from food and feedstuffs. Provision to contain effluent from fire extinguishing.
P280-P305 + P351 + P338-P310
H314
|Danger|H314 (97.77%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 179 companies from 8 notifications to the ECHA C&L Inventory.
TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE Use and Manufacturing
Trimethyl 3, 3 ', 3-phosphine triphenylpropionate (92.5 g, 0.28 mol) prepared as described above was added to a 250 ml reaction flask under mechanical stirring conditions and a molar ratio of 12 mol / (120ml, 1.44mol), the mixture was heated to 90 ° C, the solid gradually dissolved, continue to heat the reaction 4h, stirring and cooling with ice water, precipitation of white solid, filter, filter cake with distilled water to get white (2-carboxyethyl) phosphine hydrochloride, dried, weighing 61.3g, yield 82.4percent
Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assays.
Computed Properties
Molecular Weight:286.64
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:286.0373029
Monoisotopic Mass:286.0373029
Topological Polar Surface Area:112
Heavy Atom Count:17
Complexity:222
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE
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