3-BROMO-2-FLUOROPHENYLBORONIC ACID
-
3-BROMO-2-FLUOROPHENYLBORONIC ACID
structure -
-
CAS No:
352535-97-8
-
Formula:
C6H5BBrFO2
-
Chemical Name:
3-BROMO-2-FLUOROPHENYLBORONIC ACID
-
Synonyms:
3-BroMo-2-fluorobenzeneboronic acid, 98%;3-Bromo-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Categories:
-
CAS No:
Safety Information
NONH for all modes of transport
3
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
3-BROMO-2-FLUOROPHENYLBORONIC ACID Use and Manufacturing
(3-Bromo-2-fluorophenyl)boronic acid (30.0 g, 137 mmol) and 2, 4-dichloro-6-iodophenol (43.6 g, 150 mmol) were added to 400 ml of tetrahydrofuran under a nitrogen atmosphere, and the mixture was stirred and refluxed. Then, potassium carbonate (56.8 g, 411 mmol) was added by dissolving in 150 ml of water and thoroughly stirred. Tetrakistriphenyl-phosphinopalladium (4.8 g, 4 mmol) was then added thereto. After reaction for 12 hours, the temperature was lowered to room temperature, and the organic layer and the water layer were separated, and the organic layer was distilled under reduced pressure. The distillate was extracted with chloroform and water, and then the organic layer was dried with magnesium sulfate. The organic layer was dried, and then subjected to column chromatography with hexane and ethyl acetate to give Compound 4'A (36.9 g, 80%).To a schlenck flask was added Similar to as described in General Procedure X, 2-chloropyrimidine-4-carboxamide was reactedwith To 5-chloro-2-fluoro-4-iodopyridine (400 mg, 1.554 mmol) was added 3-bromo-2- fluorophenylboromc acid (340 mg, 1.554 mmol), PdCl2(dppf).CH2C12 adduct (127 mg, 0.155 mmol), DME (6.8 ml) and last 2M sodium carbonate (2.331 ml, 4.66 mmol). The reaction was stirred at 85 C for 3 hr. The reaction was followed by LCMS. The reaction was cooled, 15 ml of ethyl acetate and 5 ml of methanol was added, filtered and concentrated to crude product. The crude was purified by silica gel chromatography using 40g column eluting with 0%-10% ethyl acetate with heptane. The desired fractions were concentrated to constant mass, giving 250 mg of the titled compound as free base used without further purification. LCMS (m/z): 304.0/306.0 (MH+), rt = 1.07 mm.
suzuki reaction
Computed Properties
Molecular Weight:218.82
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:217.95500
Monoisotopic Mass:217.95500
Topological Polar Surface Area:40.5
Heavy Atom Count:11
Complexity:136
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-BROMO-2-FLUOROPHENYLBORONIC ACID
-
![China]()
CN
6 YRS
Business licensed Certified factoryManufactory Supplier of Custom Synthetic Chemicals,Biological Stains,Pharmaceutical Intermediates,Cosmetic Grade Chemicals,Enzyme,Nucleosides,Indicators,Speciality Chemicals,Biological Chemicals,Enzyme Substrates -
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives
Learn More Other Chemicals
-
3,5-DIBROMO-2-[[[(3,5-DINITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
535965-38-9
-
3,5-DIBROMO-2-[[[[(2-CHLOROPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532386-89-3
-
3,5-DIBROMO-2-[[[(4-METHYL-3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532943-48-9
-
3,5-DIBROMO-2-[[[[3-(2-FURANYL)-1-OXO-2-PROPENYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
586392-09-8
-
3,5-DIBROMO-2-[[[[(2-METHYLPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
531548-30-8
-
2-(1,8-dibromo-16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid Formula
333340-54-8
-
3,5-DIBROMO-2-[[[[3-(PHENOXYMETHYL)BENZOYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
586393-79-5
-
3,5-DIBROMO-2-[[[(4-CHLOROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
531530-32-2
-
What is 9-Octadecenoic acid (9Z)-, compd. with N,N-dimethylcyclohexanamine (1:1)
65122-23-8
-
What is 2-Cyano-3-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenoic acid
79570-01-7
3-BROMO-2-FLUOROPHENYLBORONIC ACID
SDSRequest for Quotation