(4-FLUORO-3-NITROPHENYL)ACETIC ACID

Treat a 0°C solution of 4-fluorophenylacetic acid (3 g, 19.46 mmol) in HAt 0°C, to a solution of 2-(4-fluorophenyl)acetic acid (30 g, 0.19 mol) in cone. H4-fluorophenylacetic acid (6G, 38.9 MMOL) was suspended in 50 ML H2SO4 conc. And cooled to 0°C. To this suspension was added dropwise 1.75 mi HNO3 during 30 min. and then the reaction mixture was striired at 0°C for another 3h. The yellow mixture was poured into is-water and the corresponding white crystals 4-FLUOR- 3-nitrophenylacetic acid 4. 55G, 59percent was collected and dried.Treat a 0°C solution of 4-fluorophenylacetic acid (3 g, 19.46 mmol) in HAt 0°C, to a solution of 2-(4-fluorophenyl)acetic acid (30 g, 0.19 mol) in cone. H4-fluorophenylacetic acid (6G, 38.9 MMOL) was suspended in 50 ML H2SO4 conc. And cooled to 0°C. To this suspension was added dropwise 1.75 mi HNO3 during 30 min. and then the reaction mixture was striired at 0°C for another 3h. The yellow mixture was poured into is-water and the corresponding white crystals 4-FLUOR- 3-nitrophenylacetic acid 4. 55G, 59percent was collected and dried.HATU (10.4 g, 27.5 mmol) and NaHCO3 (2.52 g, 30 mmol) were added to a CH2Cl2 (50 mL) solution of

Molecular Weight:199.14
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:199.02808583
Monoisotopic Mass:199.02808583
Topological Polar Surface Area:83.1
Heavy Atom Count:14
Complexity:240
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes