Nitric acid, beryllium salt (2:1)

133.02

132.98800

237-062-5

3VT1AXZ5LO

1352

2464

DTXSID6065555

White solid|White to faintly yellowish, deliquescent mass

126

0.56820

Clear colorless Liquid

1.56 g/cm³

60.5 °C

83ºC at 760mmHg

Solubility in water: very good

Keep well closed in a cool place.

49.8mmHg at 25°C

Abdominal cavity-mouse LD50: 0.5 mg/kg; subcutaneously-mouse LDL0: 50 mg/kg

Mixed with organic matter, reducing agent, flammable sulfur, phosphorus, combustible; combustion produces toxic nitrogen oxides and beryllium-containing fumes

Odorless

On heating above 100 °C, beryllium nitrate decomposes with simultaneous loss of water and oxides to nitrogen. Decomposition is complete above 250 °C.|Yellow-white hygroscopic crystals. MP: approximately 30 °C; BP: decomposes. Solubility: 107 g/100 g water at 20 °C; soluble in ethanol /Beryllium nitrate trihydrate/|Odorless; reacts to form weak solution of nitric acid; the reaction is not hazardous; in presence of moisture will damage wood & corrode most metals /Trihydrate/|BP: 142 °C (decomposes); MP: 60 °C. Solubility in water: 1.66X10+6 mg/L at 20 °C /Beryllium nitrate tetrahydrate/

Soluble in water.

Nitrate and Nitrite Compounds, Inorganic

Strong Oxidizing Agent

Mixtures of metal/nonmetal nitrates, such as BERYLLIUM NITRATE, with alkyl esters may explode owing to the formation of alkyl nitrates; mixing a nitrate with phosphorus, tin (II) chloride, or other reducing agents may react explosively [Bretherick 1979 p. 108-109].

In presence of moisture will damage wood and corrode most metals.

II

5.1

UN 3264 8/PG 3

1

49-23-36/38-43-48/23-36/37/38-20-34-26-21/22-8-61-45-51/53-25-48/20

53-26-36/37-45-23-36/37/39-17-61-28

DS3675000

T,T+,O,N

Low temperature drying; light loading and unloading; separate from organic matter, reducing agent, sulfur, phosphorus combustibles, food raw materials

Mixed with reducing agent, sulfur, phosphorus, etc., heated, impacted, friction can be explosive

Stable under recommended storage conditions. /Beryllium nitrate solution/

P201-P261-P280-P305 + P351 + P338-P311

H315-H317-H319-H331-H334-H350i-H373

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product. /Beryllium nitrate solution/

Oxidizing agents, Acids, Bases, Organic materials, Powdered metals, Halogenated hydrocarbon. /Beryllium nitrate solution/|Acids, caustics, chlorinated hydrocarbons, oxidizers, molten lithium. /Beryllium and beryllium compounds (as Be)/

Special Hazards of Combustion Products: Toxic and irritating beryllium oxide and oxides of nitrogen may form in fire. Behavior in Fire: May increase intensity of fire when in contact with combustible material (USCG, 1999)|Not combustible but enhances combustion of other substances. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H272 (97.44%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]|P201, P202, P210, P220, P221, P260, P261, P264, P270, P271, P272, P273, P280, P281, P284, P285, P301+P310, P302+P352, P304+P340, P304+P341, P305+P351+P338, P308+P313, P310, P312, P314, P320, P321, P330, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P370+P378, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 141 [Oxidizers - Toxic]: Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area. LARGE SPILL: Dike far ahead of spill for later disposal. (ERG, 2016)

Respiratory protection; gloves; freshly laundered clothing; chemical safety goggles (USCG, 1999)|Skin protection Handle with gloves. /Beryllium nitrate solution/|Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). /Beryllium nitrate solution/|Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). /Beryllium nitrate solution/|Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. /Beryllium nitrate solution/|For more Personal Protective Equipment (PPE) (Complete) data for BERYLLIUM NITRATE (9 total), please visit the HSDB record page.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary. /Beryllium nitrate solution/|Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. /Beryllium nitrate solution/|If material on fire or involved in fire. Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.|Evacuation. If fire becomes uncontrollable - consider evacuation of one-half (1/2) mile radius.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.|Environmental considerations: Water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.|Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. /Beryllium nitrate solution/|Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. /Beryllium nitrate solution/

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. /Beryllium nitrate solution/|If material not on fire and not involved in fire. Keep material out of water sources and sewers.|If material not involved in fire: Keep material out of water sources and sewers. /Beryllium compound, NOS/|For more Preventive Measures (Complete) data for BERYLLIUM NITRATE (8 total), please visit the HSDB record page.

/GUIDE 141: OXIDIZERS - TOXIC/ Fire or Explosion: These substances will accelerate burning when involved in a fire. May explode from heat or contamination. Some may burn rapidly. Some will react explosively with hydrocarbons (fuels). May ignite combustibles (wood, paper, oil, clothing, etc.). Containers may explode when heated. Runoff may create fire or explosion hazard.|/GUIDE 141: OXIDIZERS - TOXIC/ Health: Toxic by ingestion. Inhalation of dust is toxic. Fire may produce irritating, corrosive and/or toxic gases. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution.|/GUIDE 141: OXIDIZERS - TOXIC/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 141: OXIDIZERS - TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for BERYLLIUM NITRATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Beryllium ... nitrate ... /is an acidic salt & causes/ ... acute irritation of the eyes, skin and resp tract when ... animals are exposed to /its/ dusts ...

Permissible Exposure Limit: Table Z-2 8-hr Time Weighted Avg: 2 ug/cu m. /Beryllium and beryllium compounds/|Permissible Exposure Limit: Table Z-2 Acceptable Ceiling Concentration: 5 ug/cu m. /Beryllium and beryllium compounds/|Permissible Exposure Limit: Table Z-2 Acceptable maximum peak above the acceptable ceiling concentration for an 8-hour shift. Concentration: 25 ug/cu m. Maximum Duration: 30 minutes. /Beryllium and beryllium compounds/

NIOSH considers beryllium and beryllium compounds (as Be) to be potential occupational carcinogens. /Beryllium and beryllium compounds (as Be)/|Recommended Exposure Limit: Ceiling Value: 0.0005 mg/cu m. /Beryllium and beryllium compounds (as Be)/|NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Store only in original container. Store in an area without drain or sewer access.

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract. Inhalation of dust or fume may cause chemical pneumonitis. The effects may be delayed. Medical observation is indicated. Exposure could cause death.

Sensitization to the substance, through repeated or prolonged inhalation or skin contact, may result in serious granulomatous lung disease (chronic beryllium disease). This substance is carcinogenic to humans.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use closed system.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Beryllium compounds are included on this list. /Beryllium Compounds/

The major hazards encountered in the use and handling of beryllium nitrate stem from its toxicologic properties. Toxic primarily by inhalation and dermal contact, exposure to this odorless, white-to-slightly-yellow crystalline solid may occur from its use as a chemical reagent. Effects from exposure may include skin ulceration, headache, fatigue, fever, chest pain, pulmonary edema and possibly death from heart failure. The OSHA PEL and ACGIH TLV are set at a TWA of 2 ug/cu m. Engineering control of process equipment (eg, enclosure and local exhaust ventilation) should be used to prevent inhalation and skin contact with beryllium nitrate. In activities where over-exposure is possible, wear a self-contained breathing apparatus, goggles, gloves, and protective clothing. Work clothes should not be taken home for laundering. If contact should occur, immediately remove contaminated clothing, and flush affected skin or eyes with running water for at least 15 minutes. Beryllium nitrate may ignite other combustible materials. The substance itself burns rapidly, and may produce irritating and poisonous gases. Its reaction, particularly with fuels, may be violent. For small fires involving beryllium nitrate, extinguish with dry chemical, CO2, Halon, or water spray, and for large fires, use water spray or fog. Shipping regulations and other DOT regulatory requirements should be consulted before transport. Containers should be stored in a cool, dry place, protected from physical damage, and away from combustibles (wood, paper, oil, etc), acids, caustics, chlorinated hydrocarbons, and oxidizing materials. Small dry spills of beryllium nitrate may be shovelled into a clean, dry, covered container for later disposal. Large liquid spills should be diked far ahead of the spill to prevent runoff from causing pollution. Before implementing land disposal of beryllium nitrate waste, consult with environmental regulatory agencies for guidance.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

most toxic

The efficacy of Tiron and calcium disodium EDTA in the treatment of experimental beryllium intoxication was investigated in rats. Beryllium nitrate was administered intramuscularly (50 mg/ kg) once only, provoking duration-dependent changes. Maximum changes were recorded after a 7-day regimen. Considerable inhibition was recorded in protein and glycogen contents, as well as in the activity of alkaline phosphatase, glucose-6-phosphatase, acid phosphatase and lipid peroxidation. These parameters were restored considerably with chelation therapy, but comparatively Tiron offered better protection. These findings were further confirmed by atomic adsorption spectrophotometry. Tiron was found to be significantly more effective than CaNa(2)EDTA in reducing the beryllium concentration in the liver, kidney and lungs.|The efficacy of Tiron (4,5-dihydroxybenzene 1,3-disulfonic acid disodium salt) was examined in the treatment of beryllium-induced maternal and developmental toxicity in rats. Single administration of beryllium nitrate at a dose of 50 mg/kg (i.m.) on day 13 of gestation caused reductions in fetal and placental weights, the number of implantation sites and number of corpora lutea, as well as causing post-implantation loss, stunted growth, increase in the number of resorptions, and also a disturbed sex ratio. Maternal toxicity was demonstrated by reduction in body weight gain. Administration of beryllium also showed significant alteration in the hematological and biochemical indices of the mother as well as the fetus. Marked decreases were recorded in hemoglobin percentage, blood sugar levels, serum protein contents and serum alkaline phosphatase activity. By contrast, significant elevation was found in the activity of transaminases (aspartate aminotransferase and alanine aminotransferase). Tissue protein contents, glycogen contents, activities of alkaline phosphatase, adenosine triphosphatase and succinic dehydrogenase of kidney, lungs and uterus, and maternal and fetal liver all showed significantly decreased values after beryllium exposure, and remarkable elevation was observed in acid phosphatase, glucose-6-phosphatase and hepatic lipid peroxidation. These parameters were restored considerably with administration of 471 mg/kg i.m. Tiron from days 14 to 18 of gestation. Atomic absorption spectrophotometry also revealed a high concentration of beryllium in different organs of pregnant rats. Interestingly, a small amount of metal ion was also detected in the fetus and reduced accumulation of beryllium was noticed after Tiron treatment.|Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by treatment of aforesaid therapeutic agents for 5 consecutive days. Results were considered to be significant at p < or =0.01 and p < or =0.05. Exposure to beryllium increased its concentration in liver, kidney and serum causing significant alterations in the activity of CYP-450 2E1 system, microsomal lipid peroxidation and protein; alkaline phosphtase, lactate dehydrogenase, gamma-glutamyl transpeptidase, bilirubin, creatinine and urea in serum; activity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, glucose-6-phosphatase and succinic dehydrogenase in liver and kidney. Beryllium exposure also induced severe alterations in histopathology and ultramorphology of liver and kidney proving its toxic consequences at cellular level. Tiferron along with adjuvants dramatically reversed alterations of all variables more towards control rather than individual treatment. Study concluded that tiferron in combination with alpha-tocopherol and piperine respectively was beneficial in diluting beryllium induced systemic toxicity; however, combination of tiferron and piperine presented more pronounced therapeutic potential.|The combined effect of gallic acid (3,4,5-trihydroxy benzoic acid; GA; 50 mg/ kg i.p.) and propolis (200 mg/ kg p.o.) was evaluated against beryllium-induced biochemical and morphological alterations in the liver and kidney. Female albino rats were exposed to beryllium nitrate (1 mg/ kg i.p.) daily for 28 days followed by treatment with the above mentioned therapeutic agents either individually or in combination for five consecutive days. Exposure to beryllium increased its concentration in the serum, liver and kidney and caused significant alterations in cytochrome P450 enzymes, microsomal lipid peroxidation and protein contents. Beryllium administration significantly altered the aspartate aminotransaminase, alanine aminotransaminase, lactate dehydrogenase, gamma-grutamy1 transpeptidase, bilirubin, creatinine and urea in serum, and the activity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, glucose-6-phophatase and succinic dehydrogenase, triglycerides, cholesterol, protein contents, glycogen contents, lipid peroxidation and glutathione level in the liver and kidney. Beryllium exposure induced severe alterations in hepatorenal morphology, revealing its toxic consequences at a cellular level. Individual administration of GA and propolis reduced the effects on the studied parameters to a degree. Interestingly, GA in conjunction with propolis reversed the alterations in all of the variables examined, highlighting the beneficial effects of combined therapy over monotherapy in the alleviation of beryllium-induced systemic toxicity.|For more Interactions (Complete) data for BERYLLIUM NITRATE (17 total), please visit the HSDB record page.

Beryllium ores

Any dramatic, unexplained weight loss should be considered as possible first indication of beryllium disease. Inhalation causes pneumonitis, nasopharyngitis, tracheobronchitis, dyspnea, chronic cough. Ingestion causes anorexia, fatigue, weakness, malaise. Contact with eyes causes conjunctival inflammation. Contact with skin causes dermatitis and non-healing ulcers. (USCG, 1999)|Carcinogens

INHALATION: remove to fresh air; take chest x-ray immediately to check for pneumonitis. INGESTION: induce vomiting; get medical attention. EYES: flush with water for at least 15 min.; get medical attention. SKIN: cuts or puncture wounds in which beryllium may be embedded under the skin should be thoroughly cleansed immediately by a physician. (USCG, 1999)

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . Wear protective gloves when administering first aid.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Beryllium and Related Compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Beryllium and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Beryllium and Related Compounds/

beryllium nitrate

The substance can be absorbed into the body in hazardous amounts by inhalation of its aerosol, by ingestion and through the skin.

Cough. Laboured breathing. Shortness of breath. Sore throat. Symptoms may be delayed.

Redness. MAY BE ABSORBED!

Redness. Pain.

Grades: technical; CP.

Nitric acid, beryllium salt (2:1): ACTIVE

Health Hazards -> Carcinogens