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Methylenediphosphonic acid

Methylenediphosphonic acid structure

CAS No:
1984-15-2
Formula:
CH6O6P2
Chemical Name:
Methylenediphosphonic acid
Synonyms:
Phosphonic acid,P,P′-methylenebis-;Phosphonic acid,methylenedi-;Phosphonic acid,methylenebis-;P,P′-Methylenebis[phosphonic acid];Methanediphosphonic acid;Methylenediphosphonic acid;Methanebisphosphonic acid;MDP;Medronic acid;Methylenebis[phosphonic acid];Methylene-1,1-bisphosphonic acid;Medronate;Methane-1,1-diphosphonic acid;(Phosphonomethyl)phosphonic acid;63347-66-0
Categories:
Organic Chemistry > Phosphines

Description

Medronic Acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging.

Medronic acid is a 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups. It has a role as a bone density conservation agent and a chelator.|Medronic Acid is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes such as technetium 99m, in bone imaging.

Methylenediphosphonic acid Basic Attributes

Molecular Weight：

176

Exact Mass：

176.00

BRN：

1708494

EC Number：

217-851-0

UNII：

73OS0QIN3O

DSSTox ID：

DTXSID8045696

NCI Thesaurus Code：

C66071

HScode：

2931900090

Characteristics

PSA：

115

XLogP3：

-3.3

Appearance：

Blue Moist Crystals or Crystalline Powder

Density：

2.1±0.1 g/cm3

Melting Point：

199.5 °C

Boiling Point：

583.2°C at 760 mmHg

Flash Point：

306.5±32.9 °C

Refractive Index：

1.550

Water Solubility：

soluble in water.

Storage Conditions：

2-8°C

Vapor Pressure：

4.08E-15mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

UN 3261 8/PG 3

wgk germany：

hazard class code：

safety instructions：

26-36/37/39-45

RTECS Number：

SZ9138000

Marks：

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

H314

GHS Classification：

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

MeSH Entry Terms：

disodium methanediphosphonate

Methylenediphosphonic acid Use and Manufacturing

Radioactive imaging agent

Computed Properties

Molecular Weight:176.00
XLogP3:-3.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:175.96396190
Monoisotopic Mass:175.96396190
Topological Polar Surface Area:115
Heavy Atom Count:9
Complexity:152
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Hydrochloric acid

Drug Function and Efficacy

This product is not used directly and has no independent pharmacological or toxicological effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Stannous Methylene Diphosphonate for Injection
Ingredients	The main ingredients and chemical names of this product are: compound raw materials, which are 5mg of methylene diphosphonic acid, 0.5mg of stannous chloride, and 0.5mg of ascorbic acid. The structural formula of methylene diphosphonic acid is: Molecular formula: CH6O6P2 Molecular weight: 176
Indication	This product is not for direct use.
Specifications	Each bottle contains 5 mg of methylene diphosphonic acid and 0.5 mg of stannous chloride (SnCl2.2H2O), for one preparation
Manufacturer	HTA Co., Ltd.

Registered Holders

HUAYI ISOTOPES CO

United States
Active
P L BIOCHEMICALS

United States
Inactive
LANCASTER SYNTHESIS DIV MTM RESEARCH CHEMICALS LTD

United States
Inactive

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METHYLENEDIPHOSPHONIC ACID 99% high purity certified Professional producer Greenbo

CAS No.: 1984-15-2

Grade: Industrial Grade

Content: 99%

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Methylenebisphosphonic acid

CAS No.: 1984-15-2

Content: 99.00%

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Guide of Methylenediphosphonic acid

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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