GLYCYRRHIZIC ACID, AMMONIUM SALT, TRIHYDRATE(RG)

1. Anti-inflammatory effect: 1) Anti-allergic effect Glycyrrhizic acid glycoside has anti-allergic effects such as inhibiting local allergic necrosis reaction (Arthus Phenomenon) and inhibiting Schwartzman Phenomenon in rabbits. For corticosteroids, it enhances the hormone's stress response inhibition effect and antagonizes the hormone's anti-granulation and thymus atrophy effect. It has no effect on the exudation of hormones. 2) Inhibition of arachidonic acid metabolic enzymes Glycyrrhizic acid glycoside can directly bind to phospholipase A2, the initiator enzyme of the arachidonic acid metabolic pathway, and to lipoxygenase, which acts on arachidonic acid to produce inflammatory mediators, selectively inhibiting the phosphorylation of these enzymes and inhibiting their activation. 2. Immunomodulatory effect: Glycyrrhizic acid glycoside has the following immunomodulatory effects in in vitro experiments: 1) Regulation of T cell activation; 2) Induction of gamma interferon; 3) Activation of NK cells; 4) Promoting differentiation of extrathymic T lymphocytes. 3. Inhibition of experimental hepatocyte damage. In the rat hepatocyte cell line cultured in invitro, glycyrrhizic acid glycoside inhibited hepatocyte damage caused by carbon tetrachloride. 4. Inhibition of viral proliferation and inactivation of viruses. In the mouse MHV (mouse hepatitis virus) infection experiment, the administration of glycyrrhizic acid glycoside can prolong its survival days; in the rabbit vaccinia virus (Vacciniavirus) pox prevention experiment, it has the effect of preventing pox; in the in vitro experimental system, the inhibition of the proliferation of herpes viruses and the inactivation of viruses were also observed. It has been reported that glycine and methionine can inhibit the reduction of urine volume and sodium excretion caused by oral administration of glycyrrhizic acid glycoside to rats. 5. Non-clinical toxicology study. Acute toxicity: 12g (48 tablets) of this product per kg body weight was orally administered to rats, and no mortality was observed, so the LD50 cannot be calculated. LD50>12g (48 tablets).