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Clofilium phosphate

Clofilium phosphate structure

CAS No:
68379-03-3
Formula:
C63H111Cl3N3O4P
Chemical Name:
Clofilium phosphate
Synonyms:
Clofilium phosphate;Clofilium;LY-150378;N,N-Diethyl-N-heptyl-4-chlorobenzenebutan-1-aminium
Categories:
Organic Chemistry > Amides

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Clofilium phosphate Basic Attributes

Molecular Weight：

1111.905901

Exact Mass：

435.23100

UNII：

O1IXD77P8S

Characteristics

PSA：

80.6

XLogP3：

5.99930

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS. (See all compounds classified as Potassium Channel Blockers.)

MeSH Entry Terms：

4-chloro-N,N-diethyl-N-heptylbenzenebutanaminium

Clofilium phosphate Use and Manufacturing

Cardiac depressant (antiarrhythmic).

Computed Properties

Molecular Weight:436.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:13
Exact Mass:435.2305234
Monoisotopic Mass:435.2305234
Topological Polar Surface Area:80.6
Heavy Atom Count:28
Complexity:317
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes