Magnesium silicon oxide (Mg2Si3O8), hydrate (1:?)

278.88

269.88100

239-076-7

FML8G1U0Y3

Fine, white powder, free from grittiness|Slightly hygroscopic powder

198.80000

-2.27590

white powder

2.5

100ºC at 760mmHg

Insoluble in water

Odorless

TASTELESS

1 G WILL NEUTRALIZE APPROX 155 ML OF 0.1 N HYDROCHLORIC ACID WITHIN 4 HR|Slightly hygroscopic|Usually contains some water of hydration|Readily decomposed by mineral acids

Stable. Incompatible with mineral acids.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed over-the-counter drug products, incl magnesium trisilicate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.|Antacid products for over-the-counter (OTC) human use. Magnesium trisilicate is included on this list of specific active ingredients.|Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. Magnesium trisilicate is included as a digestive aid drug product.

Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.

An in vitro study indicated that certain antacids and adsorbents may decrease the oral availability of the two widely used antimalarial agents chloroquine and pyrimethamine. To determine if this data was applicable to the clinical (in vivo) situation, plasma levels of one of the antimalarial agents (chloroquine) were followed in six Negro--Arab volunteers both when given alone and when taken with separate doses of two of the implicated interactants (magnesium trisilicate and kaolin). This in vivo work confirmed the in vitro findings; chloroquine area under the plasma concentration-time curve data were decreased by both magnesium trisilicate (18.2%) and kaolin (28.6%). Similar results could be expected for pyrimethamine. It is suggested therefore, to avoid loss of drug, that the antimalarials should not be taken with gastrointestinal medications of this type or that their administration should be separated by at least 4 h to reduce the risk of them interacting in the gut, thus preventing drug adsorption to the antacids/adsorbents, and loss of systemic availability.|Variability in the bioavailability of orally administered trimethoprim due to magnesium trisilicate and kaolin-pectin has been investigated. The concentration of trimethoprim in blood was determined spectrofluorometrically at 0, 15 and 30 minutes and 1, 2, 4 and 6 hours. The area under the blood concentration curve of trimothoprim was significantly decreased, when the drug was given concurrently with magnesium trisilicate or kaolin-pectin. The mean decrease in maximum blood concentration of trimethoprim in magnesium trisilicate and kaolin-pectin treated groups was 49.94% and 29.42% respectively. The data suggest that a clinically significant interaction may occur due to concurrent administration of trimethoprim with these drugs.|Some steroids used in oral contraceptives were adsorbed significantly by magnesium trisilicate. The adsorption affinity followed the sequence: ethindrone greater than mestranol greater than norethindrone greater than ethinyl estradiol. ...During the dissolution testing of a brand of contraceptive tablets containing norethindrone acetate, the presence of 0.5% (w/v) magnesium trisilicate in the medium resulted in almost complete reduction in the amount of the steroid remaining in solution after 1 hr.|...The in vivo absorption characteristics of nitrofurantoin and nitrofurantoin-magnesium trisilicate combination were evaluated in 6 healthy males. Administration of magnesium trisilicate with nitrofurantoin reduced the rate and extent of its excretion reflecting decrease in both rate and extent of absorption. The time during which the drug concentration in the urine was above the minimum effective concentration of 32 microgram/ml was also significantly reduced after administration of the antacid.

33%

OCCURS IN NATURE AS THE MINERALS MEERSCHAUM, PARASEPIOLITE, & SEPIOLITE.

TERRESTRIAL FATE: Magnesium compounds are removed from soils by weathering. A major portion of soil magnesium consists of weathered primary minerals and secondary aluminosilicates in which Mg+2 ions are substituted for Al+3 ions. Silicates and aluminosilicates minerals undergo rapid surface exchange of H+ for Mg+2 ions followed by slow dissolution. As soils weather, H4SiO4 declines and magnesium silicates become more soluble. Increases in soil CO2 levels will increase the solubility of the magnesium silicates while decreasing the solubility of dolomite (CaMgCO3). In submerged soils where CO2 levels are high, dolimite will be the most stable mineral phase. Below pH 7.5, most magnesium minerals are too soluble to persist in soils. However in alkaline soils that have high concns of soluble H4SiO4, some magnesium silicates may actually form (e.g., talc, serpentine, sepiolite and chrysotolite)(1,2).

For the treatment of peptic ulcers. Relieving indigestion and heartburn.

Antacids|MEDICATION (VET): AS ANTACID & GASTRIC SEDATIVE|Three groups, each of forty children aged <5 years and prepared for elective surgery, had their gastric contents' volume and pH measured. The control group showed an incidence of 67.5% with high acidity (pH = or <2.5). In the second and third groups magnesium trisilicate mixture was given within thirty minutes prior to induction of anaesthesia. The second group, sampled after induction of anaesthesia, showed a marked reduction in acidity, while the third group, sampled at the termination of anaesthesia and surgery, demonstrated that in most cases the neutralization of gastric acidity was still effective.|Confusion exists about the correct way to use magnesium trisilicate as an antacid prior to inducing general anesthesia in the pregnant woman.|For more Therapeutic Uses (Complete) data for MAGNESIUM TRISILICATE (10 total), please visit the HSDB record page.

Chronic admin of magnesium trisilicate infrequently produces silica renal stones.

Magnesium trisilicate works by increasing the pH of gastric juice via a neutralisation reaction. It also precipitates colloidal silica, which can coat gastrointestinal mucosa conferring further protection.

Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT. (See all compounds classified as Antacids.)

The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.|Excreted in the urine.|The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.|Maximum magnesium clearance is directly proportional to creatinine clearance.|THE HYDRATED SILICON DIOXIDE...FORMED IN THE STOMACH, PASSES INTO THE INTESTINAL TRACT. SILICA CAN BE PARTLY ABSORBED & APPROX 7% OF THE SILICA OF MAGNESIUM TRISILICATE HAS BEEN REPORTED TO BE EXCRETED IN THE URINE OF HUMAN SUBJECTS.|IN RATS ADMIN ORAL MAGNESIUM TRISILICATE (0, 40, 200 OR 1000 MG/KG BODY WT) URINARY SILICON EXCRETION INCR RAPIDLY & PEAKED WITHIN 24 HR. HALF LIFE WAS 16-20 HR. URINARY SILICON EXCRETION INCR WITH DOSE LEVEL & PERCENTAGE OF SILICON EXCRETED DECR AS DOSE WAS INCR.

16-20 hours

The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.|THE GELATINOUS SILICON DIOXIDE, FORMED BY THE REACTION OF MAGNESIUM TRISILICATE WITH GASTRIC CONTENTS IS SAID TO PROTECT ULCERATED MUCOSAL SURFACES AND FAVOR HEALING.|MAGNESIUM TRISILICATE HAS A SLOW ONSET OF NEUTRALIZING ACTION; IN 0.1 N HYDROCHLORIC ACID LESS THAN 30% REACTS WITHIN 1ST 15 MIN LESS THAN 60% IN 1ST HR. ... 1 G OF POWDER WILL NEUTRALIZE 1 MEQ OF ACID IN HUMANS. 2 G/HR IS INSUFFICIENT TO RAISE...GASTRIC PH ABOVE 2.5.

/SIGNS AND SYMPTOMS/ ADEQUATE DOSES OF MAGNESIUM TRISILICATE MAY CAUSE DIARRHEA DUE TO THE ACTION OF SOLUBLE MAGNESIUM SALTS IN THE ENTERIC TRACT. APPROX 5% OF THE MAGNESIUM IS ABSORBED. THIS RESULTS IN SLIGHT REDUCTION IN THE TITRATABLE ACIDITY AND AN INCREASE IN THE PH OF THE URINE.|/CASE REPORTS/ .../IT/ IS CONSIDERED TO BE COMPLETELY INNOCUOUS WHEN TAKEN BY MOUTH. HOWEVER, A CASE OF SILICEOUS NEPHROLITH HAS BEEN REPORTED FOLLOWING CHRONIC USE.

magnesium trisilicate

MAGNESIUM TRISILICATE, USP, CONTAINS NOT LESS THAN 20% OF MG OXIDE AND NOT LESS THAN 45% OF SILICON DIOXIDE. THE POWDER CAN BE CONVENIENTLY ADMINISTERED BY SUSPENDING IT IN WATER. 1 G OF AN OFFICIAL PREPN WILL THEORETICALLY NEUTRALIZE 12-17 MEQ OF ACID.|MAGNEX TABLETS; MAGNEX POWDER; MAGNALUM.|MAGNESIUM TRISILICATE, USP. ...ORAL: POWDERY TABLETS 300 & 500 MG. AVAILABLE TRADEMARK: TRISOMIN (LILLY). DRUGS MARKETED ALSO UNDER GENERIC NAME.|MAGNESIUM TRISILICATE, USP-500 MG/5 ML, IN ALUMINUM HYDROXIDE GEL; 150 ML, 175 ML, 250 ML, 375 ML, & 1 L BOTTLES.|For more Formulations/Preparations (Complete) data for MAGNESIUM TRISILICATE (6 total), please visit the HSDB record page.

Magnesium silicon oxide (Mg2Si3O8): ACTIVE

Food additives|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Abrasive; Absorbent; Anticaking; Bulking; Opacifying; Viscosity controlling