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Halobetasol propionate

Halobetasol propionate structure

CAS No:
66852-54-8
Formula:
C25H31ClF2O5
Chemical Name:
Halobetasol propionate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-,(6α,11β,16β)-;(6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione;BMY 30056;CGP 14458;Halobetasol propionate;Ultravate;Miracorten;Ulobetasol propionate
Categories:
Organic Chemistry > Carboxylic Acids and Derivatives

Description

Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.

Solid

Halobetasol propionate Basic Attributes

Molecular Weight：

484.96

Exact Mass：

484.96

EC Number：

1592732-453-0

DSSTox ID：

DTXSID6046636

HScode：

2937229000

Characteristics

PSA：

80.7

XLogP3：

4.05110

Density：

0.934 g/mL at 25 °C(lit.)

Melting Point：

220-221 °C

Boiling Point：

55 °C0.3 mm Hg(lit.)

Flash Point：

185 °F

Refractive Index：

n20/D 1.539(lit.)

Water Solubility：

7.57e-03 g/L

Storage Conditions：

Refrigerator

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

2810

wgk germany：

hazard class code：

R22:Harmful if swallowed. R23:Toxic by inhalation. R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

S26-S36-S45-S7/9

RTECS Number：

BY4190000

Marks：

Precautionary statement(s)：

P201, P202, P260, P264, P270, P280, P281, P302+P352, P305+P351+P338, P308+P313, P314, P321, P332+P313, P337+P313, P362, P405, P501

Hazard Statements：

H315

GHS Classification：

|Danger|H315 (25%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P264, P270, P280, P281, P302+P352, P305+P351+P338, P308+P313, P314, P321, P332+P313, P337+P313, P362, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

MeSH Entry Terms：

6 alpha-fluoroclobetasol 17-propionate

Halobetasol propionate Use and Manufacturing

Uses

Anti-inflammatory; a dermatologic agent commonly used to treat psoriasis

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:485.0
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:484.1828081
Monoisotopic Mass:484.1828081
Topological Polar Surface Area:80.7
Heavy Atom Count:33
Complexity:964
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetylacetone

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