2,4-Difluorobenzyl bromide
-
2,4-Difluorobenzyl bromide
structure -
-
CAS No:
23915-07-3
-
Formula:
C7H5BrF2
-
Chemical Name:
2,4-Difluorobenzyl bromide
-
Synonyms:
Benzene,1-(bromomethyl)-2,4-difluoro-;Toluene,α-bromo-2,4-difluoro-;1-(Bromomethyl)-2,4-difluorobenzene;2,4-Difluorobenzyl bromide;α-Bromo-2,4-difluorotoluene;81228-01-5
- Categories:
-
CAS No:
2,4-Difluorobenzyl bromide Basic Attributes
207.02
207.02
4177539
245-938-3
DTXSID50178627
2903999090
Safety Information
Ⅱ
8
UN 2920 8/PG 2
3
10-34-42/43-36
23-26-36/37/39-45-25-16
C,F
Corrosive/Lachrymatory
P261-P280-P305 + P351 + P338-P310
H226-H314-H317-H334
|Danger|H226 (89.58%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P272, P280, P285, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P310, P321, P333+P313, P342+P311, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 48 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2,4-Difluorobenzyl bromide Use and Manufacturing
To a solution of compound G (450 mg, 3.12 mmol) in EtIn 500ml four-necked flask added250 mL dioxane, 45.5 g (1.52 mol)TrioxymethyleneAnd 45 g (0.39 mol) of m-difluorobenzene were added slowly, and while stirring, 300 mL (47 molpercent) of hydrobromic acid was slowly poured into it followed by 32 g (0.20 mol) of ferric chloride and the mixture was slowly heated to reflux. The reaction was dissolved for 7 hours. After completion of the HPLC assay, the reaction mixture was cooled to room temperature, Dioxane was removed under reduced pressure at 45 ° C to obtain a biphasic mixture, which was further extracted with 150 ml of methylene chloride twice and the organic layer was combined, dried over anhydrous sodium sulfate, suction filtered, and the filtrate was concentrated under reduced pressure to give a clear liquid Then, the mixture was distilled under a reduced pressure of -5 ° C to 0 ° C to collect a fraction of 60 ° C / 10 mmHg to obtain 2, 4-difluorobenzyl bromide as a colorless transparent liquid with a yield of 85.2percent and a purity of 97.8percent.
Computed Properties
Molecular Weight:207.01
XLogP3:2.7
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:205.95427
Monoisotopic Mass:205.95427
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2,4-Difluorobenzyl bromide
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives
Learn More Other Chemicals
-
Neodymium bromide (NdBr3)
13536-80-6
-
diallylnormorphinium bromide
69576-07-4
-
2,3-DICHLORO-6-(TRIFLUOROMETHYL)BENZYL BROMIDE
886501-99-1
-
1-Tetradecanaminium, N,N,N-triethyl-, bromide (1:1) Formula
18144-35-9
-
1-Butanaminium, N,N,N-tripropyl-, bromide (1:1) Formula
61175-77-7
-
1-Hexanaminium, N-butyl-2-ethyl-N,N-dimethyl-, bromide (1:1) Formula
93839-31-7
-
3-Bromo-4-fluorobenzoyl bromide Structure
78239-66-4
-
2-BROMOBENZYLZINC BROMIDE Structure
307496-27-1
-
What is 1-Dodecanaminium, N-(2-ethoxy-2-oxoethyl)-N,N-dimethyl-, bromide (1:1)
1794-75-8
-
What is Benzothiazolium, 3-(2-hydroxyethyl)-2-methyl-, bromide (1:1)
63123-34-2