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7,8-Dihydroxyflavone

7,8-Dihydroxyflavone structure

CAS No:
38183-03-8
Formula:
C15H10O4
Chemical Name:
7,8-Dihydroxyflavone
Synonyms:
4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-;Flavone,7,8-dihydroxy-;7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;7,8-Dihydroxyflavone;7,8-Dihydroxy-2-phenyl-4H-chromen-4-one
Categories:
Biochemical Engineering > Plant Extracts

Description

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

Pale yellow powder; Bland aroma

7,8-dihydroxyflavone is a dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's. It has a role as a plant metabolite, a tropomyosin-related kinase B receptor agonist, an antidepressant, an antioxidant and an antineoplastic agent.

7,8-Dihydroxyflavone Basic Attributes

Molecular Weight：

254.24

Exact Mass：

254.24

EC Number：

253-812-4

UNII：

ADB6MA8ZV2

NSC Number：

750341

DSSTox ID：

DTXSID00191568

HScode：

2914400090

Characteristics

PSA：

66.8

XLogP3：

3.3

Density：

1.4±0.1 g/cm3

Melting Point：

240-242 °C

Boiling Point：

494.4°C at 760 mmHg

Flash Point：

193.5±22.2 °C

Refractive Index：

1.699

Water Solubility：

DMSO: soluble 24mg/mL

Storage Conditions：

Store at +4°C

Collision Cross Section：

152 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

hazard class code：

safety instructions：

24/25

RTECS Number：

DJ3004000

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

6,7-dihydroxyflavone

7,8-Dihydroxyflavone Use and Manufacturing

Uses

vascular protectant, antihaemorrhagic, tyr kinase B agonist

Food Additive Classes：

Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT;

Computed Properties

Molecular Weight:254.24
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:254.05790880
Monoisotopic Mass:254.05790880
Topological Polar Surface Area:66.8
Heavy Atom Count:19
Complexity:384
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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7,8-DIHYDROXYFLAVONE 98% Light yellow crystalline powder myland

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Grade: Food Grade

Content: 98%

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7,8-Dihydroxyflavone (7,8-DHF) Powder Manufacturer CAS No.: 38183-03-8 98.0% Purity Min. For Supplement

Unit Price: $80-90 /KG FOB

CAS No.: 38183-03-8

Grade: Pharmaceutical Grade

Content: 99%

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Guide of 7,8-Dihydroxyflavone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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7,8-Dihydroxyflavone

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