Thymopentin
-
Thymopentin
structure -
-
CAS No:
69558-55-0
-
Formula:
C10H14OSn
-
Chemical Name:
Thymopentin
-
Synonyms:
32-36-Thymopoietin;L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH;Thymopoietin II-(32-36);ThyMopentin for Injection;ARG-LYS-ASP-VAL-TYR;(ASP34)-THYMOPOIETIN III (32-36) (BOVINE);H-ARG-LYS-ASP-VAL-TYR-OH;RKDVY
- Categories:
-
CAS No:
Description
Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs)[1][2].
Thymopentin is an oligopeptide.|Thymopentin is a synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties. Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle. (NCI04)|Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.
Thymopentin Basic Attributes
268.93
679.365295
2017-001-1
O3Y80ZF13F
760116
DTXSID9046609
C1294
L - Antineoplastic and immunomodulating agents
Safety Information
NONH for all modes of transport
3
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)
Pentapeptide, Thymopoietin
Thymopentin Use and Manufacturing
Preparation of thymosin-II. Raw material treatment and concentration The calf thymus was used as raw material, 0.1mol/L NH4HCO3 was added, and the mixture was extracted to obtain alkaline protein solution, which was heated to 70°C to remove denatured contaminated protein, remove the precipitate, and concentrate the supernatant. Calf thymus [0.1 mol/L NH4HCO3]→Basic protein solution [70℃, deproteinized protein]→[Concentrate] Concentrate is separated, chromatographed, purified by SephadexG-50 and hydroxyphosphorus lime column chromatography, separated, then After QAE-Sephadex column chromatography, it is purified to obtain thymosin-II concentrated solution [Sephadex G-50]→[hydroxyphosphorus lime column] chromatographic solution [QAE-Sephadex column]→thymosin-II thymosin -II extraction raw material processing, ultrafiltration, centrifugation using fresh bovine spleen as raw material, adding 0.1 mol/L NH4HCO3, homogenous extraction, to obtain alkaline soluble protein. Ultrafiltration with H10×100, the filtrate was concentrated, the water bath was heated to 70 ℃, centrifuged for 15 min, leaving the supernatant. Fresh bovine spleen [0.1 mol/L NH4HCO3] → alkaline protein solution [ultrafiltration, concentration] → [70°C, centrifugation for 15 min] The supernatant was purified through the column, the supernatant was adjusted to pH 5.2, and cation exchange resin (50 mg/ml), stir and filter, then adjust the filtrate to pH 9.5, add cation exchange resin (50mg/m1), stir and filter to obtain filtrate. Supernatant [pH5.2, cation column] → filtrate [pH9.5, cation column] → filtrate gel filtration, purification The filtrate is filtered through Sephadex G-75 gel to obtain active TP and pantothenic hormone, and then anion exchange Resin chromatography (NH4HCO3, ionic strength change 0.1-0.8mol/L), to get TP-III, heteroproteins and pan hormones. Filtrate [Sephadex G-75 gel filtration] → active TP and ubiquitin [anion resin chromatography] → TP-III, heteroprotein and ubiquitin.
immunoregulator
Computed Properties
Molecular Weight:679.8
XLogP3:-6.4
Hydrogen Bond Donor Count:11
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:22
Exact Mass:679.36532417
Monoisotopic Mass:679.36532417
Topological Polar Surface Area:328
Heavy Atom Count:48
Complexity:1110
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Extract from the above information
Registered Holders
-
Shanghai Huayuan Pharmaceutical (Ningxia) Shasai Pharmaceutical Co., Ltd.
Active
China
-
Chongqing Shengkai Pharmaceutical Co., Ltd.
Active
China
-
Youcare Pharmaceutical Group Co., Ltd.
Active
China
Recommended Suppliers of Thymopentin
-
![China]()
CN
1 YR
Business licensed Certified factoryManufactory Supplier of Semaglutide API,Tirzepatide API,Liraglutide API,Linaclotide API,Creatine Monohydrate,Copper Tripeptide-1,Linaclotide,Teriparatide,Octreotide Acetate,Ganirelix Acetate,Bivalirudin,Icatibant Acetate,Eptifibatide,Ziconotide Acetate,Lanreotide Acetate,Abaloparatide Acetate,Terlipressin Acetate,Atosiban Acetate,Carbetocin Acetate,Enfuvirtide,Exenatide,Levosimendan,Somatostatin,Thymopentin,Thymosin alpha1,Retatrutide,Cagrilintide,Leuprorelin,Cetrorelix,Degarelix,Plecanatide,Acetyl Hexapeptide-8,Dipeptide Diaminobutyroyl Benzylamide Diacetate,Nonapeptide-1,Palmitoyl Pentapeptide-4,Palmitoyl Tetrapeptide-7,Hexapeptide-9,Arginine/Lysine Polypeptide,Palmitoyl Tripeptide-5,,Pentapeptide-3,Carnosine,Acetyl Tetrapeptide-2,Acetyl Tetrapeptide-3InquiryCAS No.: 69558-55-0Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization -
![China]()
CN
5 YRS
Business licensedTrader Supplier of cosmetic peptide -
![China]()
CN
4 YRS
Business licensedTrader Supplier of additives,pharmaceutical chemicals,organic intermediate,chemical intermediates,Pharmaceutical Intermediates,catalyst,APIInquiryCAS No.: 69558-55-0Grade: Pharmaceutical gradeContent: 99% -
![China]()
CN
7 YRS
Business licensed Certified factoryManufactory Supplier of Cosmetic peptides,beauty raw materials,custom peptides,pharmaceutical intermediatesInquiryUnit Price: $20-25 /UNIT FOBCAS No.: 69558-55-0Grade: Chemical GradeContent: 98%
Learn More Other Chemicals
-
THYMOPENTIN
177966-81-3
-
ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
15958-92-6
-
CLIP
53917-42-3
-
Trilysine Formula
13184-14-0
-
Alanylasparagine Formula
31796-57-3
-
2-[[(2S)-3-phenyl-2-[[(2R)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]acetic acid Formula
75539-79-6
-
L-Arginyl-L-phenylalanyl-L-alanine Structure
67368-27-8
-
BNP-45 (RAT) Structure
123337-89-3
-
What is 2-[[2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]propanoic acid
17123-30-7
-
What is 4-(3-BROMOBENZYL)MORPHOLINE
364793-82-8