N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester
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![N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/a187619847844e979cbbce6af1776894.png "N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester")
N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester
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CAS No:
882757-24-6
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Formula:
C24H37N4O6PS
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Chemical Name:
N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester
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Synonyms:
N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester;Alanine, N,N'-[[5-[2-aMino-5-(2,2-diMethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-Methyl-, 1,1'-diethyl ester;MB-07803;Alanine,N,N'-[[5-[2-amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]pho sphinylidene]bis[2-methyl-,diethyl ester
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CAS No:
Description
MB07803 is an orally available prodrug of a potent, noncompetitive inhibitor (MB07729) of fructose 1,6-bisphosphatase (FBPase), with EC50 of 140 nM and t1/2 of 7.6±2.9 h.
MB07803 is a second generation gluconeogenesis inhibitor for the treatment of type 2 diabetes. It is designed to block the metabolic pathway in the liver that is responsible for producing glucose.
N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester Basic Attributes
540.618
556.212
GG81XF45C2
DTXSID90236932
Drug Information
Investigated for use/treatment in diabetes mellitus type 2.
MB07803 is a selective inhibitor of fructose-1, 6-bisphosphatase (FBPase), a regulatory enzyme in the pathway responsible for the production of glucose in the liver, known as the gluconeogenesis pathway. By specifically inhibiting this pathway, liver glucose production should be reduced and blood sugar levels decreased in patients with diabetes, independent of insulin levels and body weight.
Computed Properties
Molecular Weight:556.6
XLogP3:3.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:14
Exact Mass:556.21205770
Monoisotopic Mass:556.21205770
Topological Polar Surface Area:191
Heavy Atom Count:37
Complexity:872
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester
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