Fmoc-L-Dapa-OH
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Fmoc-L-Dapa-OH
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CAS No:
181954-34-7
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Formula:
C18H18N2O4
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Chemical Name:
Fmoc-L-Dapa-OH
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Synonyms:
L-ALANINE, 3-AMINO-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-;N-α-Fmoc-L-2,3-diaminopropionic acid;N-α-Fmoc-L-2,3-diaminopropionic acid hydrochloride;N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-2,3-diaminopropionicacidhydrocholrid;N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-L-2,3-DIAMINOPROPIONIC ACID HYDROCHLORID;N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-2,3-diaminopropionic acid;N-.ALPHA. -FMOC-L-2,3-DIAMINOPROPIONIC ACID HYDROCHLORIDE;FMOC-L-2,3-DIAMINOPROPIONIC ACID
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CAS No:
Characteristics
102
-0.5
1.324±0.06 g/cm3(Predicted)
579.5±50.0 °C(Predicted)
301.9±30.1 °C
1.643
2-8°C
2.85E-14mmHg at 25°C
2.77±0.16(Predicted)
2-8°C
Fmoc-L-Dapa-OH Use and Manufacturing
To a stirred solution of sodium bicarbonate (0.154 g)and Na-Fmoc, L-diamino propionic acid (0.5 g, 1.53 mmol) in 1: 1 water and acetonitrile mixture (4 mE) was added 4-chloro-7-nitrobenzo-2-oxa-l , 3-diazole (0.367 g, 1.836 mmol). The reaction mixture was allowed to stir overnight. Solvent was removed using rotary evaporation, and the remaining crude was purified by flash chromatograph on silica gel (CH2C12: MeOH=l0:3) with trance acetic acid to give product as brown solid (0.482 g, 0.985 mmol, 64.3%). 'H NMR (400 MHz, DMSO, 25 C.) oe 3.80 (bs, 2H), 4.15 (t, J=8.4 Hz, 1H), 4.28 (d, J=9.2 Hz, 2H), 4.37 (m, 1H), 6.48 (d, J=ll.6 Hz, 1H), 7.24 (t, J=9.6 Hz, 2H), 7.35 (m, 2H), 7.60 (d, J=l0.0 Hz, 2H), 7.63 (d, J=l0.4 Hz, 1H), 7.85 (d, J=l0.0 Hz, 2H), 8.48 (d, J=l0.4 Hz, 1H).
peptide synthesis
Computed Properties
Molecular Weight:326.3
XLogP3:-0.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:326.12665706
Monoisotopic Mass:326.12665706
Topological Polar Surface Area:102
Heavy Atom Count:24
Complexity:448
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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