FMOC-12-AMINODODECANOIC ACID

White to off-white powder

Fmoc-OSu (6.55 g; 21.9 mmol) and NaHCO3 (2.39 g; 28.5 mmol) were added to a solution of12-aminododecanoic acid (4.71 g; 21.9 mmol) in acetone (90 mL) and water (90 mL), and then themixture was stirred at rt for 20 h. The reaction mixture was quenched with concentrated HCl until pH4–5, and the resulting precipitate was extracted into with EtOAc (3 x 50 mL). The resulting combinedorganic phases were dried with Na2SO4, filtered, and evaporated. The crude product was purifiedon a silica column (Hexane–EtOAc 3:1) to provide Fmoc-12-aminododecanoic acid (4.20 g; 43percent) asa white solid. 1H NMR and 13C NMR were as reported [28].

Molecular Weight:437.6
XLogP3:6.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:15
Exact Mass:437.25660860
Monoisotopic Mass:437.25660860
Topological Polar Surface Area:75.6
Heavy Atom Count:32
Complexity:544
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes