Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1)

White to greyish-beige powder

It can be obtained by adding cyclohexanone and nitromethane, and then reducing it with iron powder. Add methanol, nitromethane, and cyclohexanone into the reaction tank, stir, and control the temperature at 5-10°C. Add sodium hydroxide solution dropwise. After the addition, cool to -4°C, stir for 1 hour, and centrifuge for filtration. Recover methanol from the filtrate, dissolve the filter cake with water, acidify with acetic acid below 10°C to pH 4-5, heat to 30°C to completely dissolve, separate the oil layer to obtain nitromethyl cyclohexanol, and perform the reduction operation in the reaction tank first Add water, iron powder and 2/3 of the total amount of hydrochloric acid, control pH 5-6, temperature 40-50 ℃, drop by one step to obtain nitromethyl cyclohexanol crude oil, keep warm and stir after adding, add every 1 hour 1/6 hydrochloric acid, add 1/3 of the total amount of hydrochloric acid in 2 times, maintain pH 5-6, continue stirring for 2 hours, and then filter while hot. The filtrate is a methylcyclohexanol salt solution.

Pharmaceutical intermediates for the production of guanethidine.

Molecular Weight:165.66
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:165.0920418
Monoisotopic Mass:165.0920418
Topological Polar Surface Area:46.2
Heavy Atom Count:10
Complexity:86.9
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes