4-(4-Aminophenyl)butyric acid

From the condensation of succinic anhydride and acetanilide to generate β-acetamidobenzoylpropionic acid, which is then obtained by reduction. Put aluminum trichloride and carbon disulfide into a dry reaction pot, stir and cool to 7-8°C and quickly put in a homogeneous mixture of acetanilide and succinic anhydride, and after vigorous reflux, continue the reaction at 30-45°C for 1 hour. Let it stand for 2d, add crushed ice to stir and decompose, filter after 1h, wash the filter cake and dissolve it with 5% sodium bicarbonate solution, add activated carbon to decolorize, filter, the filtrate is acidified with 1.5N hydrochloric acid to pH=1 to obtain an off-white solid. It is filtered, washed with water, dried, and refined with absolute ethanol to obtain β-acetamidobenzoylpropionic acid, with a melting point of 196-200°C, and a yield of 35.4%. Put β-acetamidobenzoylpropionic acid and hydrazine hydrate in a dry reaction pot, heat to an external temperature of 140-160℃, keep it for 20 minutes and then cool to below 100℃. The reactant is brownish-yellow solid. Add hydrogen slowly After potassium oxide is completely dissolved, it is reheated to an external temperature of 140°C to start denitrification, and the temperature is continued to rise to 180°C. The reactant changes from thick to porous yellow pine solid. The total denitrification time is about 1h. After denitrification is completed, cool, add water to dissolve, add activated carbon to decolorize and filter, the filtrate is neutralized with 6N hydrochloric acid to pH 6, and then adjusted to pH 5-6 with glacial acetic acid, milky white crystals are precipitated, filtered, washed with water, and dried in vacuum to obtain 4-(p-amino Benzene) butyric acid. The yield was 85%.

Medicinal intermediates, used in the synthesis of tumor Ning.

Molecular Weight:179.22
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:179.094628657
Monoisotopic Mass:179.094628657
Topological Polar Surface Area:63.3
Heavy Atom Count:13
Complexity:162
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes