5-Aminopyrimidine-4-carboxylic acid

The 5 - nitro-indole - 2, 3 - dione (192 mg, 1 mmol) and 1, 8 - diazabicyclo eleven carbon -7 - ene (304 mg, 2 mmol) dissolved in N, N - in dimethyl formamide (1 ml), stirring at the room temperature for ten minutes. The 5 - amino pyrimidine -4 - carboxylic acid (138 mg, 1 mmol), N - methyl morpholine (202 mg, 2 mmol), O - benzo triazole - four oneself hexafluoro phosphate (380 mg, 1 mmol) dissolved in N, N - in dimethyl formamide (2 ml), the reaction of the isatin with drop of DBU added into the solution in the solution, stirring at room temperature for 20 hours. To evaporate the solvent, column chromatography (dichloromethane: methanol=80:1) to obtain the orange-yellow solid (403 mg, 67%) is 8 - nitro-pyrimido [5 ', 4': 4, 5] pyrimido [1, 2 - a] indole - 6, 12 - dione (compound 5).The 5 - nitro-indole - 2, 3 - dione (192 mg, 1 mmol) and 1, 8 - diazabicyclo eleven carbon -7 - ene (304 mg, 2 mmol) dissolved in N, N - in dimethyl formamide (1 ml), stirring at the room temperature for ten minutes. The 3 - amino pyrazine -2 - formic acid (139 mg, 1 mmol), N - methyl morpholine (202 mg, 2 mmol), O - benzo triazole - four oneself hexafluoro phosphate (380 mg, 1 mmol) dissolved in N, N - in dimethyl formamide (2 ml), the reaction of the isatin with drop of DBU added into the solution in the solution, stirring at room temperature for 20 hours. To evaporate the solvent, column chromatography (dichloromethane: methanol=80:1) to obtain the orange-yellow solid (412 mg, 69%) is 8 - nitro indole [2, 1 - b] pteridine - 6, 12 - dione (compound 7).15 g of To a stirred mixture of To a stirred mixture of

Molecular Weight:139.11
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:139.038176411
Monoisotopic Mass:139.038176411
Topological Polar Surface Area:89.1
Heavy Atom Count:10
Complexity:139
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes