N-Boc-1-aminocyclobutanecarboxylic acid
-
N-Boc-1-aminocyclobutanecarboxylic acid
structure -
-
CAS No:
120728-10-1
-
Formula:
C10H17NO4
-
Chemical Name:
N-Boc-1-aminocyclobutanecarboxylic acid
-
Synonyms:
N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID;1-AMINOCYCLOBUTYL-1-CARBOXYLIC ACID, N-BOC PROTECTED;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID;1-N-BOC-AMINO-CYCLOBUTANE CARBOXYLIC ACID;1-(TERT-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID;1-TERT-BUTOXYCARBONYLAMINO-CYCLOBUTANECARBOXYLIC ACID;1-(T-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID;BOC-AC4C-OH
- Categories:
-
CAS No:
Characteristics
75.6
1.2
White to light brown Powder
1.18±0.1 g/cm3(Predicted)
129-133 °C(lit.)
362.1±21.0 °C(Predicted)
172.8±22.1 °C
1.500
2-8°C
3.16E-06mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
22
36
Xn
P305 + P351 + P338
H302-H319
|Warning|H302 (89.13%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
N-Boc-1-aminocyclobutanecarboxylic acid Use and Manufacturing
To a stirred solution of 1-aminocyclobutane-1-carboxylic acid (2 g, 17 mmol) in 1, 4- dioxane: HTo a stirred solution of 1-aminocyclobutane-l-carboxylic acid (30 g, 139.53 mmol, 1.0 eq) in 1, 4-dioxane (300 ml) at 0 °C was added 2N NaOH solution (300 ml) followed by (Boc)Stage 1. 1 -[(tert-Butoxycarbonyl)am ino]cyclobutanecarboxyl ic acid To a solution of 1-amino-1-cyclobutane carboxylic acid (2.92 g, 25.4 mmol), NaOH (3.04 g, 76.2 mmol), THF (100 mL) and water (100 mL) at RT was added d-tert-buty dcarbonate (8.30 g, 38.1 rnmoD and the reaction was strred for 24 hrs, The reacUon mixture was acdfled to pH5 usng 2M HC and the mixture was extracted w[th EtOAc (2x 200 mL). The cornbned organcs were dried over MgSO4, ifitered and concentrated in vacuo to give the tWe compound as a whfte sod (1.05 g, 19percent). LCMS: m/z 238 [M+Hj.Intermediate 68 1-({[(1, 1-dimethylethyl)oxy]carbonyl}amino)cyclobutanecarboxylic acid [0684] [0685] To a solution of 1-aminocyclobutanecarboxylic acid (626 mg, 5.44 mmol) in 5.6 ml of 1 M aqueous sodium hydroxide and 4 ml of methanol was added Boc-anhydride (1.425 g, 6.53 mmol) at 0° C. The reaction mixture was warmed to room temperature and stirred for 12 hours. After most of the methanol was evaporated, the solution was acidified to pH 2 with 1 M HCl and extracted with ethyl acetate. The organic extracts were combined and washed with brine. Evaporation of the solvent afforded the title compound (1.09 g). [0686] Reference Example F-2
Computed Properties
Molecular Weight:215.25
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:215.11575802
Monoisotopic Mass:215.11575802
Topological Polar Surface Area:75.6
Heavy Atom Count:15
Complexity:276
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of N-Boc-1-aminocyclobutanecarboxylic acid
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of fine chemicals,pharmaceutical materialsInquiryCAS No.: 120728-10-1Grade: industrial GradeContent: 98% -
![China]()
CN
3 YRS
Business licensedTrader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVEInquiryCAS No.: 120728-10-1Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
2 YRS
Business licensedTrader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic AcidInquiryCAS No.: 120728-10-1Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
3,5-DIBROMO-2-[[[(3,5-DINITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
535965-38-9
-
3,5-DIBROMO-2-[[[[(2-CHLOROPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532386-89-3
-
3,5-DIBROMO-2-[[[(4-METHYL-3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532943-48-9
-
3,5-DIBROMO-2-[[[[3-(2-FURANYL)-1-OXO-2-PROPENYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
586392-09-8
-
3,5-DIBROMO-2-[[[[(2-METHYLPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
531548-30-8
-
2-(1,8-dibromo-16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid Formula
333340-54-8
-
3,5-DIBROMO-2-[[[[3-(PHENOXYMETHYL)BENZOYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
586393-79-5
-
3,5-DIBROMO-2-[[[(4-CHLOROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
531530-32-2
-
What is 9-Octadecenoic acid (9Z)-, compd. with N,N-dimethylcyclohexanamine (1:1)
65122-23-8
-
What is 2-Cyano-3-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenoic acid
79570-01-7
N-Boc-1-aminocyclobutanecarboxylic acid
SDSRequest for Quotation