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(R)-(-)-2-Amino-1-propanol

(R)-(-)-2-Amino-1-propanol structure

CAS No:
35320-23-1
Formula:
C3H9NO
Chemical Name:
(R)-(-)-2-Amino-1-propanol
Synonyms:
D-Alaninol, 98%, ee: 98%;(R)-(-)-2-AMINOPROPANOL;(R)-(-)-2-AMINO-1-PROPANOL;H-DL-ALA-OL;D-ALAOH;D-(-)-ALANINOL;D-2-AMINO-PROPANOL;D - aMino propanol
Categories:
Pharmaceutical Intermediates > Ophthalmic Agents

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Description

Colorless to light yellow liqui

(R)-(-)-2-Amino-1-propanol is a chiral secondary amine.

(R)-(-)-2-Amino-1-propanol Basic Attributes

Molecular Weight：

75.11

Exact Mass：

75.068413

BRN：

1718866

EC Number：

629-219-5

UNII：

770ZI70L3Q

Color/Form：

Clear colorless to light yellow

HScode：

29221990

Characteristics

PSA：

46.2

XLogP3：

-1

Appearance：

Clear colorless to light yellow Oily Liquid

Density：

0.965

Melting Point：

8 °C

Boiling Point：

173-176 °C(lit.)

Flash Point：

183 °F

Refractive Index：

n20/D1.450(lit.)

Water Solubility：

SOLUBLE

Storage Conditions：

2-8°C

Specific rotation：

-17 º (c=neat)

PKA：

12.88±0.10(Predicted)

Critical Temperature & Pressure：

Keep in dark place,Inert atmosphere,2-8°C

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 2735 8/PG 2

wgk germany：

hazard class code：

C,Xi

safety instructions：

26-36/37/39-45-36

Marks：

C,Xi

Hazard note：

Corrosive/Hygroscopic

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

34-36/37/38

RIDADR：

UN 2735 8/PG 2

GHS Classification：

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 51 companies from 4 notifications to the ECHA C&L Inventory.

(R)-(-)-2-Amino-1-propanol Use and Manufacturing

Methods of Manufacturing

The present embodiment relates to a class of long-chain ethyl piperazine sulfonamide derivative intermediate () in the general synthetic methods.Particularly to the synthesis of L- propylamine alcohol.The 150mL dry THF and 1.1gLiAlH(R)-Alanine (10.0 g, 112 mmol) was added solwly to a mixture of lithium aluminium hydride (8.50 g, 224 mmol) in dry THF (300ml) at 0. The mixture was refluxed for 6h, water (8.50 ml) was added slowly, stirred for 15min. Then 15percent NaOH aqueous solution(8.5 ml) was added to the mixture. The crude product was purified by vacuum distillation (Bp: 54 (700Pa)) to give (R)-Alaniol(6.15 g) as a colorless liquid in yield of 73percent.A solution of E1 (19.0 g, 184.5 mmol) in THF (300 ml_) was cooled to 0 °C, and LiAIHExample 26. Separation of rac.-1, 2-propanediol using a chiral selector generated from (4R, 5R)-bis(hydroxydiphenylmethyl)-2, 2-dimethyl-1, 3-dioxolane and Ti(O-isopropyl)

Uses

Used in organic synthesis, used as emulsifier

(R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.

Computed Properties

Molecular Weight:75.11
XLogP3:-1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:75.068413911
Monoisotopic Mass:75.068413911
Topological Polar Surface Area:46.2
Heavy Atom Count:5
Complexity:22.9
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 35320-23-1

Content: 99.00%

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H-D-His-OH

CAS No.: 35320-23-1

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CAS No.: 35320-23-1

Grade: Pharmaceutical grade

Content: 99%

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Guide of (R)-(-)-2-Amino-1-propanol

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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(R)-(-)-2-Amino-1-propanol

SDS

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