N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine
-
![N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/b3fd8bf8b5104eb59371b79f11fac223.png "N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine")
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine
structure -
-
CAS No:
200115-86-2
-
Formula:
C19H30N4O5S
-
Chemical Name:
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine
-
Synonyms:
L-Ornithine,N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-;N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine;(2S)-2-Amino-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]pentanoic acid
- Categories:
-
CAS No:
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine Basic Attributes
426.535
426.53
606-419-0
DTXSID20428601
Characteristics
166
-1
1.39±0.1 g/cm3(Predicted)
636.9°C at 760 mmHg
339ºC
1.617
Store at 0-5°C
4.27E-17mmHg at 25°C
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine Use and Manufacturing
To the aqueous phase containing crude amine 3b was added sodium hydroxide (1 M aqueous, 6 mL, 6 mmol, 2 equiv). Di-fe /-butyl dicarbonate (864 mg, 3.97 mmol, 1.3 equiv) was dissolved in dioxane (20 mL, 0.15 M) and added. The mixture was stirred (19 h), concentrated under reduced pressure, diluted with water (30 mL) and sodium carbonate (5% aqueous, 3 mL, producing pH = 9), washed with ether (40 mL), acidified with hydrochloric acid (1 M aqueous, until pH = 1), extracted with ethyl acetate (3 x 30 mL), and dried with sodium sulfate. Volatiles were removed under reduced pressure to yield pure carbamate 3c (quantitative), a fraction of which was used directly in the next step. Product analysis is consistent with commercially available material.5 1H NMR (CDC13, 400 MHz) 6.58-6.30 (m, 3H), 5.65-5.55 (brs, 1H), 4.25 (q, J= 6.6 Hz, 1H), 3.25-3.10 (brs, 2H), 2.93 (s, 2H), 2.53 (s, 3H), 2.47 (s, 3H), 2.07 (s, 3H), 1.95- 1.55 (m, 4H), 1.44 (s, 6H), 1.41 (s, 9H).Synthesis of carbamate 3c Into a flask were added Fmoc-Arg(Pbf)-OH (1.98 g, 3.05 mmol, 1 equiv), dioxane (10 mL, 0.3 M), water (5 mL, 0.6 M), and lithium hydroxide (2 M aqueous, 4.6 mL, 9.2 mmol, 3 equiv). The mixture was stirred (2.5 h, producing precipitate), diluted with water (10 mL), and washed with EtOAc (20 mL). The aqueous phase was used directly in the next step.
Computed Properties
Molecular Weight:426.5
XLogP3:-1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:426.19369124
Monoisotopic Mass:426.19369124
Topological Polar Surface Area:166
Heavy Atom Count:29
Complexity:733
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 200115-86-2Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
L-Cysteine
52-90-4
-
1-chloro-6-Methyl-5-nitroisoquinoline
943606-84-6
-
2-chloro-N-(2-oxothiolan-3-yl)acetamide
84611-22-3
-
N-[(Phenylmethoxy)carbonyl]-L-phenylalanylglycine Formula
13122-99-1
-
(αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid Formula
50890-96-5
-
3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide Formula
461000-66-8
-
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Structure
2420-17-9
-
γ-Aminobenzenepropanol Structure
14593-04-5
-
What is tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
170491-63-1
-
What is (R)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
774178-39-1
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine
SDSRequest for Quotation