(RS)-3,5-DHPG
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(RS)-3,5-DHPG
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CAS No:
146255-66-5
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Formula:
C8H9NO4
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Chemical Name:
(RS)-3,5-DHPG
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Synonyms:
DL-ALPHA-(3,5-DIHYDROXYPHENYL)GLYCINE;(RS)-3,5-DHPG;(RS)-3,5-DIHYDROXYPHENYLGLYCINE;Benzeneacetic acid, α-amino-3,5-dihydroxy-;2-amino-2-(3,5-dihydroxyphenyl)acetic acid;a-Amino-3,5-dihydroxy-benzeneacetic acid HCl;DHPG,mGluR,Inhibitor,inhibit,Metabotropic glutamate receptors;DHPG ((RS)-3，5-DHPG)
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CAS No:
Description
ChEBI: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
2-amino-2-(3,5-dihydroxyphenyl)acetic acid is an alpha-amino acid.
Characteristics
104
0.88250
1.550±0.06 g/cm3(Predicted)
448.8±33.0 °C(Predicted)
225.2ºC
Soluble in water (10mM)
1.77±0.10(Predicted)
Store at -20°C
Drug Information
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)|Drugs that bind to and activate excitatory amino acid receptors. (See all compounds classified as Excitatory Amino Acid Agonists.)
3,5-DHPG
(RS)-3,5-DHPG Use and Manufacturing
(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. It has been shown that (RS)-3,5-DHPG can modulate Kir4.1 protein and mRNA in cultured rat retinal Müller cells.(RS)-3,5-DHPG acts as a potential target in treatment of parkinson''s disease.
Computed Properties
Molecular Weight:183.16
XLogP3:-2.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:183.05315777
Monoisotopic Mass:183.05315777
Topological Polar Surface Area:104
Heavy Atom Count:13
Complexity:187
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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