FMOC-D-LYS(MTT)-OH

White to off-white powder

The Dde protection group on Lys 2 was removed by 2% hydrazine, and compound 3 was obtained by building the peptide sequence Ac-Cys-Ahx-Ahx-dLys-Ahx- on the epsilon-amino group of the Lys of compound 2 using an AAPPTEC 396 omega multiple peptide synthesizer (AAPPTEC, Louisville, KY) employing standard Fmoc chemistry and standard SPPS. The permanent protection groups chosen for the amino acid side chains were: Trt for Cys and Mtt for Lys. Trt and Mtt protection groups were selected based on an orthogonal protection scheme. The Mtt protecting group was selected to protect Lys so that the Mtt could be removed without removing other protecting groups. For example, the Trt on Cys will not come off in 1% TFA but the Mtt on Lys can be removed in 1% TFA. In certain embodiments, other orthogonal protection schemes can be used. The Fmoc protecting groups were removed at every subsequent cycle by treatments with 20% Piperidine for 10 min. The peptide chain was assembled by sequential acylation (20 min for coupling) with 'in situ' activated Fmoc-amino acids. Re- coupling was automatically performed at every cycle. (0456) [0236] The 'in situ' activations of Fmoc-amino acids (3 eq. compared to the resin amount) were carried out using uronium salts (HBTU, 2.7 eq., HOBT 3 eq.) and DIEA (6 eq.).

Molecular Weight:624.8
XLogP3:6.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:14
Exact Mass:624.29880776
Monoisotopic Mass:624.29880776
Topological Polar Surface Area:87.7
Heavy Atom Count:47
Complexity:942
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes