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Fmoc-leucine

Fmoc-leucine structure

CAS No:
35661-60-0
Formula:
C21H23NO4
Chemical Name:
Fmoc-leucine
Synonyms:
L-Leucine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine;N-(9-Fluorenylmethoxycarbonyl)-L-leucine;N-(9-Fluorenylmethoxycarbonyl)leucine;NPC 15199;N-(Fluorenylmethoxycarbonyl)leucine;N-FMOC-leucine;Fmoc-leucine;NSC 334290;908: PN: WO2006135786 PAGE: 58 claimed protein;217: PN: US20070042401 PAGE: 29 claimed protein;(2S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-4-methylpentanoic acid;Fmoc-L-Leucine;(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid;(2S)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-4-methylpentanoic acid;725247-22-3
Categories:
Pharmaceutical Intermediates > Antibacterials

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Description

white to light yellow crystal powde

Fmoc-leucine Basic Attributes

Molecular Weight：

353.41

Exact Mass：

353.41

BRN：

2178254

EC Number：

252-662-7

UNII：

KF18F70UF3

DSSTox ID：

DTXSID0040751

HScode：

2924299090

Characteristics

PSA：

75.6

XLogP3：

4.4

Appearance：

White crystalline powder

Density：

1.2±0.1 g/cm3

Melting Point：

144-146 °C (decomp)

Boiling Point：

559.8°C at 760 mmHg

Flash Point：

292.4±25.4 °C

Refractive Index：

1.583

Storage Conditions：

2-8°C

Specific rotation：

-26 º (c=1,DMF 24 ºC)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

22-24/25-36/37/39-27-26

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 8 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

N-(fluorenyl-9-methoxycarbonyl)leucine

Fmoc-leucine Use and Manufacturing

General procedure: To a solution of H-Phe-OH (100 mg, 60.5 mmol) in 50 percent MeCN (6.1 mL)were added Fmoc-OPhth (233 mg, 60.5 mmol) and K2CO3 (167 mg, 121 mmol) and stirred at room temperature. After 2 h of stirring saturated sodium bicarbonate solution and H2O were added and the resulting solution was washed with diethyl ether. The aqueous phase is acidified to pH 1 with 1M HCl and extracted with diethyl ether. The organic phase was washed with 1 M HCl, H2O, brine, dried over MgSO4. The filtrate was evaporatedevaporated under reduced pressure to give yellow solid as crude product.EXAMPLE 22

Computed Properties

Molecular Weight:353.4
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:353.16270821
Monoisotopic Mass:353.16270821
Topological Polar Surface Area:75.6
Heavy Atom Count:26
Complexity:484
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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